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[pTyr¹¹⁵⁰/Tyr¹¹⁵¹]Insulin receptor monoclonal antibody (10C3)



ADI-905-645-100	100 µg	513.00 USD
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Alternative Name:	INSR

Clone:	10C3

Host:	Mouse

Isotype:	IgG1

Immunogen:	Synthetic peptide corresponding to a portion of human Insulin Receptor phosphorylated at Tyr^1150/1151, conjugated to KLH.

UniProt ID:	P06213

Species reactivity:	Human

Crossreactivity:	Cross-reacts with IGF1 receptor.

Applications:	ELISA, WB

Recommended Dilutions/Conditions:	ELISA (0.1µg/ml) Western Blot (0.2-0.5µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application.

Purity Detail:	Thiophilic adsorption and size exclusion chromatography purified.

Formulation:	Liquid. In PBS containing 50% glycerol, PEG, sucrose, and 0.09% sodium azide.

Use/Stability:	Stable at -20°C up to 1 year.

Shipping:	Shipped on Blue Ice

Long Term Storage:	-20°C

Scientific Background:	The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.

Regulatory Status:	RUO - Research Use Only