| ADI-905-645-100 | 100 µg | 528.00 USD |  |
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| Alternative Name: | INSR |
| Clone: | 10C3 |
| Host: | Mouse |
| Isotype: | IgG1 |
| Immunogen: | Synthetic peptide corresponding to a portion of human Insulin Receptor phosphorylated at Tyr1150/1151, conjugated to KLH. |
| UniProt ID: | P06213 |
| Species reactivity: | Human |
| Crossreactivity: | Cross-reacts with IGF1 receptor. |
| Applications: | ELISA, WB |
| Recommended Dilutions/Conditions: | ELISA (0.1µg/ml) Western Blot (0.2-0.5µg/ml, ECL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Thiophilic adsorption and size exclusion chromatography purified. |
| Formulation: | Liquid. In PBS containing 50% glycerol, PEG, sucrose, and 0.09% sodium azide. |
| Use/Stability: | Stable at -20°C up to 1 year. |
| Shipping: | Blue Ice |
| Long Term Storage: | -20°C |
| Scientific Background: | The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes. |
| Regulatory Status: | RUO - Research Use Only |
![[pTyr1150/Tyr1151]Insulin receptor monoclonal antibody (10C3) Western blot](https://www.enzolifesciences.com/fileadmin/files/image/905-645_WB.jpg "[pTyr1150/Tyr1151]Insulin receptor monoclonal antibody (10C3) Western blot")
![[pTyr1150/Tyr1151]Insulin receptor monoclonal antibody (10C3) Western blot](https://www.enzolifesciences.com/fileadmin/thumbs/2ad953760914c51e67aba13b93ab6eac86a7ffac-905-645_WB.jpg.jpg "[pTyr1150/Tyr1151]Insulin receptor monoclonal antibody (10C3) Western blot")
