Replaces Prod. #: ALX-804-295
Product Details
| Alternative Name: | Cyt c |
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| Clone: | 6H2.B4 |
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| Host: | Mouse |
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| Isotype: | IgG1 |
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| Immunogen: | Native rat Cytochrome c. |
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| UniProt ID: | P62898 |
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| Source: | Purified from hybridoma tissue culture supernatant. |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | ELISA, IP
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| Application Notes: | Estimated molecular weight of ~13kDa. |
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| Purity Detail: | Protein G affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.1% sodium azide. Concentration 1mg/ml. |
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| Handling: | Avoid freeze/thaw cycles. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Scientific Background: | Cytochrome c, which is a critical component of the electron transport chain, is a component of the functional apoptosome. Upon release from the mitochondria, cytochrome c binds to the adaptor proteins Apaf-1 and procaspase-9 to form a cytosolic apoptosome complex. This event results in activation of procaspase-9 and its subsequent cleavage and activation of caspase-3 leading to the degradation of a series of cellular substrates and subsequently cell death. |
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| Regulatory Status: | RUO - Research Use Only |
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