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Stat5α polyclonal antibody

ADI-905-556-1 1 ml 326.00 USD
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Product Details

Alternative Name:Signal transducer and activator of transcription 5α
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human Stat5α.
UniProt ID:P42229
Gene/Protein Identifier:6776 (Entrez GeneID)
Species reactivity:Human, Mouse, Rat
Applications:IHC, WB
Recommended Dilutions/Conditions:Immunohistochemistry (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~95kDa by Western blot.
Purity Detail:Affinity purified.
Formulation:Liquid. In PBS, pH 7.6, containing 1% BSA and 0.1% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:The signal transducer and activator of transcription (STAT) proteins serve as both cytoplasmic signaling and nuclear transcription activating proteins. STAT family proteins are comprised of an N -terminal domain that facilitates binding of cofactors, central DNA binding and SH2 domains, and a C -terminal transactivation domain. In response to a specific cytokine signal, STAT proteins are phosphorylated on conserved tyrosine residues. Phosphorylated STAT proteins dimerize via their SH2 domains and move to the nucleus. The STAT dimers bind to specific DNA elements resulting in transcriptional regulation of downstream target genes. STAT5 consists of two highly related genes encoding STAT5α and STAT5β proteins, which are 96% similar at the amino acid level. STAT5 is activated by phosphorylation at Tyr694 (STAT5α) or Tyr699 (STAT5β) in response to prolactin, growth hormone, thrombopoietin, erythropoietin, GM-CSF, IL-2, IL-3, IL-5, IL-7, IL-9, and IL-15 signals. Studies in knockout mice indicate STAT5α is the principal mediator of mammary gland development and lactogenesis.
Regulatory Status:RUO - Research Use Only
Stat5α polyclonal antibody Western blot
Western Blot analysis of K562 cell lysate with Stat5α pAb.
Stat5α polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of breast carcinoma stained with STAT5a pAb.
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Stat5α polyclonal antibody Western blot Stat5α polyclonal antibody Immunohistochemistry

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