Product Specification
| Alternative Name: | Interstitial collagenase, Collagenase-1, Matrix metalloproteinase 1 |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to the sequence near the C-terminus of human MMP-1. |
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| UniProt ID: | P03956 |
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| Gene/Protein Identifier: | 4312 (Entrez GeneID) |
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| Species reactivity: | Human
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| Applications: | IHC
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| Recommended Dilutions/Conditions: | Immunohistochemistry (1:200)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Purity Detail: | Affinity purified. |
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| Formulation: | Liquid. In 10mM PBS, pH 7.4, containing BSA and sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | Matrix metalloproteinases (MMP) are proteolytic enzymes capable of degrading connective tissue components. Imbalanced secretion of certain MMPs or disturbances in the differential control of MMPs by tissue inhibitor of MMPs (TIMPs) is implicated in the invasive potential of malignant tumors. Interstitial collagenase (MMP-1), 72kDa gelatinase A / type IV collagenase (MMP-2), and 92 kDa gelatinase B / type IV collagenase (MMP- 9) dissolve extracellular matrix (ECM) and may initiate and promote angiogenesis. |
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| Regulatory Status: | RUO - Research Use Only |
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Immunohistochemistry analysis of human placenta stained with MMP-1, pAb.
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Product Literature References
Eliminating Regurgitation Reduces Fibrotic Remodeling of Functional Mitral Regurgitation Conditioned Valves: P.S. Connell, et al.; Ann. Biomed. Eng.
46, 670 (2018),
Abstract;
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