Alternative Name: | Interleukin-21 |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to the sequence near the middle of human IL-21. |
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UniProt ID: | Q9HBE4 |
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Species reactivity: | Human
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Applications: | ICC, WB
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Recommended Dilutions/Conditions: | Immunocytochemistry (2µg/ml) Western Blot (0.5-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~18kDa by Western blot. |
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Purity Detail: | Peptide affinity purified. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Shipping: | Blue Ice Not Frozen |
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Long Term Storage: | +4°C |
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Scientific Background: | IL-21 is a cytokine identified in human and mouse that shows significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R) also termed NILR for novel interleukin receptor) is a member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling via the JAK-Stat pathway. IL-21 is expressed in activated T-cells, as well as HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B- and T-cell populations. |
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Regulatory Status: | RUO - Research Use Only |
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