| Alternative Name: | TRP53, Tumor protein p53 |
| |
| Host: | Rabbit |
| |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human p53DINP1. The is completely conserved between α and β isoforms. |
| |
| UniProt ID: | Q96A56 |
| |
| Species reactivity: | Human, Mouse, Rat
|
| |
| Applications: | IHC, WB
|
| |
| Recommended Dilutions/Conditions: | Immunohistochemistry (2µg/ml)
Western Blot (1-2µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
| |
| Application Notes: | Detects a band of ~27kDa by Western blot. |
| |
| Purity Detail: | Peptide affinity purified. |
| |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| |
| Shipping: | Blue Ice Not Frozen |
| |
| Long Term Storage: | +4°C |
| |
| Scientific Background: | p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
