Alternative Name: | TRP53, Tumor protein p53 |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human p53DINP1. The is completely conserved between α and β isoforms. |
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UniProt ID: | Q96A56 |
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Species reactivity: | Human, Mouse, Rat
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Applications: | IHC, WB
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Recommended Dilutions/Conditions: | Immunohistochemistry (2µg/ml) Western Blot (1-2µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~27kDa by Western blot. |
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Purity Detail: | Peptide affinity purified. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Shipping: | Blue Ice Not Frozen |
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Long Term Storage: | +4°C |
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Scientific Background: | p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to Mdm2, SV40 T antigen and human Papilloma virus E6 protein. p53 senses DNA damage and facilitates its repair. Mutation involving p53 is found in a wide variety of malignant tumors, including breast, ovary, bladder, colon, lung, and melanoma. |
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Regulatory Status: | RUO - Research Use Only |
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