| ADI-905-290-100 | 100 µg | 470.00 USD |  |
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| Alternative Name: | β site APP cleaving enzyme, β-Secretase 2 |
| Host: | Rabbit |
| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human BACE2. |
| UniProt ID: | Q9Y5Z0 |
| Species reactivity: | Human, Mouse, Rat |
| Applications: | IHC, WB |
| Recommended Dilutions/Conditions: | Immunohistochemistry (10µg/ml) Western Blot (0.5-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Application Notes: | Detects a band of ~70kDa by Western blot. |
| Purity Detail: | Peptide affinity purified. |
| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
| Shipping: | Blue Ice Not Frozen |
| Long Term Storage: | +4°C |
| Scientific Background: | Accumulation of the amyloid-beta (Abeta) plaque, which is linked with the pathogenesis of Alzheimer's disease, is generated by proteolytic cleavage of the beta-amyloid protein precursor (APP) at beta- and gamma-sites by two proteases. APP is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99 amino acid carboxy-terminal fragment (C99). beta-secretase was identified by several groups independently and designated beta-site APP cleaving enzyme (BACE) and Aspartyl protease 2 (Asp2). BACE/Asp2 is a transmembrane aspartic protease and colocalizes with approximately |
| Regulatory Status: | RUO - Research Use Only |
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