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ADAM17 (CT) polyclonal antibody

ADI-905-249-100 100 µg 492.00 USD
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Product Details

Alternative Name:TACE, A disintegrin and metalloproteinase 17
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human ADAM17.
UniProt ID:P78536
Species reactivity:Human, Mouse, Rat
Applications:ICC, WB
Recommended Dilutions/Conditions:Western Blot (1:500-1:2,000)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects bands of ~80 to ~130kDa (may represent mature protein, precursor, and glycosylated TACE) by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Blue Ice
Long Term Storage:-20°C
Scientific Background:TNF-alpha converting enzyme (TACE) is a membrane-bound metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), and is responsible for the cleavage of membrane-bound precursor TNF-alpha to its mature, secreted form. TACE also processes other cell surface proteins, including TNF receptor, TGFalpha, the L-selectin adhesion molecule, and alpha-cleavage of amyloid protein precursor (APP).
Regulatory Status:RUO - Research Use Only
ADAM17 (CT) polyclonal antibody Western blot
Western blot analysis of TACE in HeLa and Jurkat whole cell lysate in the absence or presence of blocking peptide with TACE antibody at 1:500 dilution.
ADAM17 (CT) polyclonal antibody Immunocytochemistry
Immunocytochemistry analysis of TACE in HeLa cells with TACE antibody at 10µg/ml.
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ADAM17 (CT) polyclonal antibody Western blot ADAM17 (CT) polyclonal antibody Immunocytochemistry

Product Literature References

GPR37 is processed in the N-terminal ectodomain by ADAM10 and furin: S.O. Mattila, et al.; FASEB J. 35, e21654 (2021), Abstract;
Rivastigmine modifies the α-secretase pathway and potentially early Alzheimer's disease: B. Ray, et al.; Transl. Psychiatry 10, 81 (2020), Abstract; Full Text
High Glucose Upregulates ADAM17 through HIF-1α in Mesangial Cells: R. Li, et al.; J. Biol. Chem. 290, 21603 (2015), Application(s): Immunofluorescence, Abstract; Full Text

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