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Smac/DIABLO (CT) polyclonal antibody

ADI-905-244-100 100 µg 458.00 USD
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Product Details

Alternative Name:Second mitochondria-derived activator of caspase
Immunogen:Synthetic peptide corresponding to the sequence near the C-terminus of human Smac/DIABLO.
UniProt ID:Q9NR28
Species reactivity:Human, Mouse, Rat
Applications:IHC, WB
Recommended Dilutions/Conditions:Immunohistochemistry (5µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~25kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:+4°C
Scientific Background:Smac/DIABLO is one of the pro-apoptotic proteins normally found in the intermembrane space of the mitochondria. In response to apoptotic stimuli, Smac/DIABLO is released into the cytosol resulting in permeabilization of the mitochondrial membrane. Cytosolic Smac/DIABLO activates caspase-9 by binding IAP proteins. Changes in the expression level of Smac/DIABLO have been demonstrated in a number of human cancers including melanoma, ovary, and prostate.
Regulatory Status:RUO - Research Use Only
Smac/DIABLO (CT) polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of Smac/DIABLO in human ovary tissue with Smac antibody at 5µg/ml.
Smac/DIABLO (CT) polyclonal antibody Western blot
Western blot analysis of Smac in human heart tissue lysate in the absence (A) or presence (B) of blocking peptide with Smac antibody at 1µg /ml.
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Smac/DIABLO (CT) polyclonal antibody Immunohistochemistry Smac/DIABLO (CT) polyclonal antibody Western blot

Product Literature References

Cardiolipin or MTCH2 can serve as tBID receptors during apoptosis: E. Raemy, et al.; Cell Death Differ. 23, 1165 (2016), Application(s): Western blot, Abstract;

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