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RIP3 polyclonal antibody

ADI-905-242-100 100 µg 481.00 USD
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Product Details

Alternative Name:Receptor-interacting serine/threonine protein kinase 3, RIP-like protein kinase 3, Receptor-interacting protein 3
Immunogen:Synthetic peptide corresponding to a portion of mouse RIP3.
UniProt ID:Q9QZL0
Species reactivity:Mouse, Rat
Applications:IHC (PS), WB
Recommended Dilutions/Conditions:Immunohistochemistry (paraffin sections, 5µg/ml)
Western Blot (0.5-1.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~57kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Blue Ice
Short Term Storage:+4°C
Long Term Storage:-20°C
Scientific Background:A member in the RIP kinase family was identified and designated RIP3 (Receptor-interacting serine/threonine protein kinase-3). RIP3 contains an N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNF-R1, mediates TNF-R1 induced apoptosis, and attenuates RIP and TNF-R1 induced NF-κB activation.
Regulatory Status:RUO - Research Use Only
RIP3 polyclonal antibody Western blot
Western blot analysis of RIP3 in mouse 3T3 whole cell lysate in the absence (A) or presence (B) of blocking peptide with RIP3 antibody at 1µg/ml.
RIP3 polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of RIP3 in rat kidney tissue with RIP3 antibody at 5µg/ml.
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RIP3 polyclonal antibody Western blot RIP3 polyclonal antibody Immunohistochemistry

Product Literature References

Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation: L. Laurien, et al.; Nat. Commun. 11, 1747 (2020), Abstract; Full Text
Caspase-8, receptor-interacting protein kinase 1 (RIPK1), and RIPK3 regulate retinoic acid-induced cell differentiation and necroptosis: M. Someda, et al.; Cell Death Differ. 27, 1539 (2020), Abstract; Full Text
Gut Barrier Dysfunction Induced by Aggressive Fluid Resuscitation in Severe Acute Pancreatitis is Alleviated by Necroptosis Inhibition in Rats: Q.R. Cui, et al.; Shock 52, e107 (2019), Abstract;
Glucocorticoid receptor dimers control intestinal STAT1 and TNF-induced inflammation in mice: M. Ballegeer, et al.; J. Clin. Invest. 128, 3265 (2018), Abstract; Full Text
LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis: N. Peltzer, et al.; Nature 557, 112 (2018), Abstract; Full Text
PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation: S.W. Choi, et al.; Mol. Cell 70, 920 (2018), Abstract;
Targeting intestinal epithelial cell–programmed necrosis alleviates tissue injury after intestinal ischemia/reperfusion in rats: X. Li, et al.; J. Surg. Res. 225, 117 (2018), Abstract;
TNFR2 unlocks a RIPK1 kinase activity-dependent mode of proinflammatory TNFR1 signaling: D. Siegmund, et al.; Cell. Death. Dis. 9, 921 (2018), Abstract; Full Text
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC5: N. Van Opdenbosch, et al.; Cell Rep. 21, 3427 (2017), Abstract; Full Text
Kinase-independent functions of RIPK1 regulate hepatocyte survival and liver carcinogenesis: T.M. Van, et al.; J. Clin. Invest. 127, 2662 (2017), Abstract; Full Text
Mitochondrial permeabilisation engages NF-κB dependent anti-tumour activity under caspase deficiency: E. Giampazolias, et al.; Nat. Cell Biol. 19, 1116 (2017), Abstract;
Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia/reperfusion injury: S. Wen, et al.; J. Cell. Mol. Med. 21, 432 (2017), Abstract; Full Text
The linear ubiquitin chain assembly complex regulates TRAIL-induced gene activation and cell death: E. Lafont, et al.; EMBO J. 36, 1147 (2017), Abstract; Full Text
Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria: A. Korwitz, et al.; J. Cell Biol. 212, 157 (2016), Abstract; Full Text
NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-κB-Dependent and -Independent Functions: K. Vlantis, et al.; Immunity 44, 553 (2016), Application(s): Immunoblotting, Abstract;
NEMO regulates a cell death switch in TNF signaling by inhibiting recruitment of RIPK3 to the cell death-inducing complex II: A. Pescatore, et al.; Cell Death Dis. 7, e2346 (2016), Application(s): Cell stimulation and immunoprecipitation, MEF cells, Abstract; Full Text

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