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PUMA (NT) polyclonal antibody

ADI-905-237-100 100 µg 458.00 USD
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Product Details

Immunogen:Synthetic peptide corresponding to the sequence near the N-terminus of human PUMAα.
UniProt ID:Q9BXH1
Species reactivity:Human
Applications:IHC, WB
Recommended Dilutions/Conditions:Immunohistochemistry (10µg/ml)
Western Blot (2-4µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application.
Application Notes:Detects a band of ~23kDa by Western blot.
Purity Detail:Peptide affinity purified.
Formulation:Liquid. In PBS containing 0.02% sodium azide.
Shipping:Blue Ice Not Frozen
Long Term Storage:-20°C
Scientific Background:PUMA, the p53 upregulated modulator of apoptosis gene, encodes for two BH3 domain-containing proteins referred to PUMAa and PUMAb1. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce Cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis.
Regulatory Status:RUO - Research Use Only
PUMA (NT) polyclonal antibody Western blot
Western blot analysis of PUMA expression in K562 cell lysate with PUMA antibody at 2µg /ml.
PUMA (NT) polyclonal antibody Immunohistochemistry
Immunohistochemistry analysis of PUMA in human breast carcinoma with PUMA antibody at 10µg/ml.
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PUMA (NT) polyclonal antibody Western blot PUMA (NT) polyclonal antibody Immunohistochemistry

Product Literature References

Increased expression of importin-β, exportin-5 and nuclear transportable proteins in Alzheimer's disease aids anatomic pathologists in its diagnosis: G. Nuovo, et al.; Ann. Diag. Pathol. 32, 10 (2018), Application(s): Immunohistochemistry on human brain FFPE tissue, Abstract;

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