| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to the sequence near the N-terminus of human PHAP. |
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| UniProt ID: | P39687 |
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| Species reactivity: | Human, Mouse, Rat
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| Applications: | IHC, WB
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| Recommended Dilutions/Conditions: | Western Blot (0.5-2.0µg/ml)
Suggested dilutions/conditions may not be available for all applications.
Optimal conditions must be determined individually for each application. |
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| Application Notes: | Detects a band of ~28kDa by Western blot. |
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| Purity Detail: | Peptide affinity purified. |
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| Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Scientific Background: | The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were identified as important regulators of mitochondrial mediated apoptosis. PHAP appears to facilitate apoptosome mediated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both ras- and myc mediated cell transformation. |
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| Regulatory Status: | RUO - Research Use Only |
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