Alternative Name: | Caspase recruitment domain-containing protein 9 |
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Host: | Rabbit |
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Immunogen: | Synthetic peptide corresponding to aa 521-536 of human CARD-9. |
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UniProt ID: | Q9H257 |
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Species reactivity: | Human
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Applications: | ICC, WB
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Recommended Dilutions/Conditions: | Immunocytochemistry (10µg/ml) Western Blot (0.5-1.0µg/ml) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
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Application Notes: | Detects a band of ~59kDa by Western blot. |
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Purity Detail: | Peptide affinity purified. |
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Formulation: | Liquid. In PBS containing 0.02% sodium azide. |
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Shipping: | Blue Ice Not Frozen |
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Long Term Storage: | +4°C |
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Scientific Background: | Apoptotic cell death signals are transduced by death domain (DD), death effector domain (DED), and caspase recruitment domain (CARD) containing molecules. CARD-9 interacts with the CARD activation domain of BCL-10, a pro-apoptotic activator of NF-κB. CARD-9 is thought to act as a scaffold for the assembly of BCL10 signaling complexes associated with the activation of NF-κB. |
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Regulatory Status: | RUO - Research Use Only |
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