Alternative Name: | Secretory leukocyte proteinase inhibitor, ALP, Antileukoproteinase |
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Clone: | D12 |
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Host: | Mouse |
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Isotype: | IgG |
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Immunogen: | Recombinant protein corresponding to aa 25-132 of human SLPI (His-tagged). |
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UniProt ID: | P03973 |
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GenBank ID: | 758101 |
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Gene/Protein Identifier: | 6590 (Gene ID), OTTHUMP00000031775 (Protein ID) |
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Species reactivity: | Human
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Applications: | ELISA, WB
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Application Notes: | Detects a band of ~13kDa by Western blot. |
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Purity Detail: | Protein G-affinity purified. |
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Formulation: | Liquid. In 1X PBS, pH 7.4, containing 10% glycerol and 0.05% sodium azide. |
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Shipping: | Shipped on Blue Ice |
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Long Term Storage: | -20°C |
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Scientific Background: | The ALP (antileukoproteinase) or SLPI (secretory leukocyte peptidase inhibitor) protein is a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. The ALP protein is also thought to have broad-spectrum antibiotic activity. |
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Regulatory Status: | RUO - Research Use Only |
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