- Highly sensitive, detecting as low as 34.2 pg/ml IGF-1
- Broad dynamic range suitable for use with a variety of samples
- High throughput format with results for up to 40 samples in duplicate in just 4 hours
- Fully quantitative results that surpass semi-quantitative Western blot analysis
The IGF-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 4 hours. Absorbance is read at 450 nm. This kit offers ultra-sensitive measurement of as little as 34.2 pg/ml of IGF-1.
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Product Specification
| Alternative Name: | Insulin-like growth factor 1 |
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| Sensitivity: | 34.2 pg/ml (range 187 - 6,000 pg/ml) |
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| Assay Time: | 4 hours |
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| Applications: | ELISA, Colorimetric detection
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| Application Notes: | For the quantitative determination of human IGF-1 in plasma and serum. Cited sample types include culture supernatants and milk. |
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| Species reactivity: | Human
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| Crossreactivity: | Human IGF-1 (100%), human IGF-2 (0.11%) and <0.1%: IGFBP-2, IGFBP-3, IGFBP-4, mouse IGF-1, mouse IGF-2, HGH, HGF, PDGF-BB, human insulin |
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| Shipping: | Blue Ice Not Frozen |
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| Long Term Storage: | +4°C |
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| Contents: | Microtiter plate, Conjugate, Antibody, Assay buffer 10 concentrate, Standard, Wash buffer concentrate, TMB substrate, Stop solution 2, Neutralizing reagent 2, 2N HCl |
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| Scientific Background: | Insulin-like growth factor-I (IGF-I) is a polypeptide hormone similar in structure to insulin. It is involved in regulation of neuronal growth and development in the central and peripheral nervous system. IGF-1 is a potent inhibitor of apoptosis in neurons, and activates the Akt signaling pathway via the IGF-1R and Insulin receptors. The IGF-1R acts as a receptor for IGF-1 and the related IGF-2, and is subject to autophosphorylation on multiple tyrosine residues that regulate receptor activation and assembly of signal transduction complexes. |
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| Technical Info/Product Notes: | Cited samples:
Cytokine ELISAs Cited Samples |
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| UniProt ID: | P05019 |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dietary lysine affects amino acid metabolism and growth performance, which may not involve the GH/IGF-1 axis, in young growing pigs: M. Shamimul Hasan, et al.; J. Anim. Sci.
98, skaa004 (2020),
Application(s): Pig plasma,
Abstract;
Predicting the vulnerability of birds to trophic threat posed by phenological mismatch based on nutritional and physiological status of nestlings: S. Zhang, et al.; Conserv. Physiol.
7, coz096 (2019),
Application(s): Birds plasma,
Abstract;
Full Text
3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds: W. Lee, et al.; Sci. Rep.
6, 29408 (2016),
Application(s): Preparation of drug-releasing micro particles,
Abstract;
Full Text
Daily overfeeding from protein and/or carbohydrate supplementation for eight weeks in conjunction with resistance training does not improve body composition and muscle strength or increase markers indicative of muscle protein synthesis and myogenesis in resistance-trained males: M. Spillane, et al.; J. Sports Sci. Med.
15, 17 (2016),
Application(s): IGF-1 in human serum,
Abstract;
Full Text
Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease: L.M. McGinley, et al.; Stem Cells Transl. Med.
5, 379 (2016),
Application(s): Growth factor production and signaling,
Abstract;
Full Text
Influence of Porcine Plasma Supplementation on Gestating Sow Serum IGF-1 Concentration and Litter Weights: M. Vaughn, et al.; PAWJ
4, 6 (2016),
Application(s): Serum samples were assayed in triplicate,
Full Text
Normalization of patient-identified plasma biomarkers in SMNΔ7 mice following postnatal SMN restoration: W.D. Arnold, et al.; PLoS One
11, e0167077 (2016),
Application(s): IGF-1 in human plasma,
Abstract;
Full Text
The growth endocrine axis and inflammatory responses after laparoscopic cholecystectomy: T. Floros, et al.; Hormones
15, 73 (2016),
Application(s): IGF-1 in human serum,
Abstract;
Changes in maternal body composition and metabolism of dairy goats during pregnancy: D. S. Castagnino, et al.; R. Bras. Zootec.
44, 92 (2015),
Application(s): ELISA using goat plasma,
Full Text
Contents of Breast Milk Obtained from Mothers of Preterm and Term Newborn Infants: D. Terek, et al.; JPR
2, 183 (2015),
Application(s): Milk IGF-1 levels in the mother’s breast milk,
Full Text
Residual feed intake and blood variables in young Nellore cattle: C.F. Nascimento, et al.; J. Anim. Sci.
93, 1318 (2015),
Application(s): Extracted bovine blood plasma,
Abstract;
Association Between Omentin, Visfatin and Insulin-Like Growth Factor-1 in Women With Metabolic Syndrome: M.T. Goodarzi, et al.; Avicenna J. Med. Biochem.
2, e25184 (2014),
Application(s): ELISA,
Full Text
Directed axonal outgrowth using a propagating gradient of IGF‐1: W. Lee, et al.; Adv. Mater.
26, 4936 (2014),
Application(s): Total IGF-1 amount was determined,
Abstract;
Electrochemical immunosensor for the determination of insulin-like growth factor-1 using electrodes modified with carbon nanotubes–poly(pyrrole propionic acid) hybrids: V. Serafín, et al.; Biosens. Bioelectron.
52, 98 (2014),
Application(s): Human Serum,
Abstract;
Heavy resistance training and peri-exercise ingestion of a multi-ingredient ergogenic nutritional supplement in males: effects on body composition, muscle performance and markers of muscle protein synthesis: M. Spillane, et al.; J. Sports. Sci. Med.
13, 894 (2014),
Application(s): Quantification of IGF-1 in serum samples,
Abstract;
Full Text
The effect of bovine colostrum supplementation in older adults during resistance training: W.R. Duff, et al.; Int. J. Sport Nutr. Exerc. Metab.
24, 276 (2014),
Abstract;
Effects of velvet antler with blood on bone in ovariectomized rats: S.H. Tseng, et al.; Molecules
17, 10574 (2012),
Application(s): ELISA using ether extract of velvet antler,
Abstract;
Full Text
Effects of 28 days of resistance exercise while consuming commercially available pre- and post-workout supplements, NO-Shotgun and NO-Synthesize: M. Spillane, et al.; Nutr. Metab. (Lond.)
8, 78 (2011),
Application(s): ELISA using human serum,
Abstract;
Full Text
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