Highly sensitive, detecting as low as 34.2 pg/ml IGF-1
Broad dynamic range suitable for use with a variety of samples
High throughput format with results for up to 40 samples in duplicate in just 4 hours
Fully quantitative results that surpass semi-quantitative Western blot analysis
The IGF-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 4 hours. Absorbance is read at 450 nm. This kit offers ultra-sensitive measurement of as little as 34.2 pg/ml of IGF-1.
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Product Specification
Alternative Name:
Insulin-like growth factor 1
Sensitivity:
34.2 pg/ml (range 187 - 6,000 pg/ml)
Assay Time:
4 hours
Applications:
ELISA, Colorimetric detection
Application Notes:
For the quantitative determination of human IGF-1 in plasma and serum. Cited sample types include culture supernatants and milk.
Species reactivity:
Human
Crossreactivity:
Human IGF-1 (100%), human IGF-2 (0.11%) and <0.1%: IGFBP-2, IGFBP-3, IGFBP-4, mouse IGF-1, mouse IGF-2, HGH, HGF, PDGF-BB, human insulin
Insulin-like growth factor-I (IGF-I) is a polypeptide hormone similar in structure to insulin. It is involved in regulation of neuronal growth and development in the central and peripheral nervous system. IGF-1 is a potent inhibitor of apoptosis in neurons, and activates the Akt signaling pathway via the IGF-1R and Insulin receptors. The IGF-1R acts as a receptor for IGF-1 and the related IGF-2, and is subject to autophosphorylation on multiple tyrosine residues that regulate receptor activation and assembly of signal transduction complexes.
Dietary lysine affects amino acid metabolism and growth performance, which may not involve the GH/IGF-1 axis, in young growing pigs: M. Shamimul Hasan, et al.; J. Anim. Sci. 98, skaa004 (2020), Application(s): Pig plasma, Abstract;
Predicting the vulnerability of birds to trophic threat posed by phenological mismatch based on nutritional and physiological status of nestlings: S. Zhang, et al.; Conserv. Physiol. 7, coz096 (2019), Application(s): Birds plasma, Abstract; Full Text
3D patterned stem cell differentiation using thermo-responsive methylcellulose hydrogel molds: W. Lee, et al.; Sci. Rep. 6, 29408 (2016), Application(s): Preparation of drug-releasing micro particles, Abstract; Full Text
Daily overfeeding from protein and/or carbohydrate supplementation for eight weeks in conjunction with resistance training does not improve body composition and muscle strength or increase markers indicative of muscle protein synthesis and myogenesis in resistance-trained males: M. Spillane, et al.; J. Sports Sci. Med. 15, 17 (2016), Application(s): IGF-1 in human serum, Abstract; Full Text
Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease: L.M. McGinley, et al.; Stem Cells Transl. Med. 5, 379 (2016), Application(s): Growth factor production and signaling, Abstract; Full Text
Influence of Porcine Plasma Supplementation on Gestating Sow Serum IGF-1 Concentration and Litter Weights: M. Vaughn, et al.; PAWJ 4, 6 (2016), Application(s): Serum samples were assayed in triplicate, Full Text
Normalization of patient-identified plasma biomarkers in SMNΔ7 mice following postnatal SMN restoration: W.D. Arnold, et al.; PLoS One 11, e0167077 (2016), Application(s): IGF-1 in human plasma, Abstract; Full Text
The growth endocrine axis and inflammatory responses after laparoscopic cholecystectomy: T. Floros, et al.; Hormones 15, 73 (2016), Application(s): IGF-1 in human serum, Abstract;
Changes in maternal body composition and metabolism of dairy goats during pregnancy: D. S. Castagnino, et al.; R. Bras. Zootec. 44, 92 (2015), Application(s): ELISA using goat plasma, Full Text
Contents of Breast Milk Obtained from Mothers of Preterm and Term Newborn Infants: D. Terek, et al.; JPR 2, 183 (2015), Application(s): Milk IGF-1 levels in the mother’s breast milk, Full Text
Residual feed intake and blood variables in young Nellore cattle: C.F. Nascimento, et al.; J. Anim. Sci. 93, 1318 (2015), Application(s): Extracted bovine blood plasma, Abstract;
Association Between Omentin, Visfatin and Insulin-Like Growth Factor-1 in Women With Metabolic Syndrome: M.T. Goodarzi, et al.; Avicenna J. Med. Biochem. 2, e25184 (2014), Application(s): ELISA, Full Text
Directed axonal outgrowth using a propagating gradient of IGF‐1: W. Lee, et al.; Adv. Mater. 26, 4936 (2014), Application(s): Total IGF-1 amount was determined, Abstract;
Electrochemical immunosensor for the determination of insulin-like growth factor-1 using electrodes modified with carbon nanotubes–poly(pyrrole propionic acid) hybrids: V. Serafín, et al.; Biosens. Bioelectron. 52, 98 (2014), Application(s): Human Serum, Abstract;
Heavy resistance training and peri-exercise ingestion of a multi-ingredient ergogenic nutritional supplement in males: effects on body composition, muscle performance and markers of muscle protein synthesis: M. Spillane, et al.; J. Sports. Sci. Med. 13, 894 (2014), Application(s): Quantification of IGF-1 in serum samples, Abstract; Full Text
The effect of bovine colostrum supplementation in older adults during resistance training: W.R. Duff, et al.; Int. J. Sport Nutr. Exerc. Metab. 24, 276 (2014), Abstract;
Effects of velvet antler with blood on bone in ovariectomized rats: S.H. Tseng, et al.; Molecules 17, 10574 (2012), Application(s): ELISA using ether extract of velvet antler, Abstract; Full Text
Effects of 28 days of resistance exercise while consuming commercially available pre- and post-workout supplements, NO-Shotgun and NO-Synthesize: M. Spillane, et al.; Nutr. Metab. (Lond.) 8, 78 (2011), Application(s): ELISA using human serum, Abstract; Full Text
Produced in baculovirus. The 46kDa cytoplasmic domain of the ß-subunit of human IGF-1 receptor kinase (IGF-1RK ) (aa 929-1337) is fused to GST. | Print as PDF
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