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Molecular Chaperones / Heat Shock Proteins

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HSPs [HSP90, HSP70/40, HSP60/10, GroEL/ES & more]
Heme Oxygenases
Small HSPs [Crystallin, HSP20, HSP25, HSP27 & more]
Co-Chaperones & HSP-interacting Proteins
HSF
Mitochondrial HSPs [Mortalin, Grp75]
ER Stress [ERp57, ERp72, Grp94, Calnexin, Calnexin & more]
Neurodegenerative Diseases
Clusterin
More Stress & HSPs

All Stress & HSPs

Selected Literature

Heat Shock Protein Chaperone Complexes - Wallchart

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Download as pdf

Heat Shock Proteins & the Cellular Stress Response Catalog

HSP70/HSP40 Complexes - Technical Brief

HSP90 - Scientific Review

Enzo Life Sciences is your exclusive source for the comprehensive portfolio of Stressgen® products specific to the analysis of Heat Shock Proteins (HSP) and chaperones. Products include: inhibitors, substrates, proteins, antibodies, kits and a host of other products specific for HSPs, co-chaperones, and client proteins.

Enzo Life Sciences ELISA kits offer an easy and reproducible way to quantify various heat shock proteins including HSP70 and HSP90α.

HSP70 High Sensitivity ELISA Kit

Only commercially available kit sensitive enough and specifically validated for quantifying HSP70 (HSP72) in serum and plasma samples.

  • Sensitive – quantify as little as 90pg/ml HSP70 (HSP72)
  • Reliable – fully validated for use with serum and plasma samples
  • Specific – measure stress-induced HSP70 (HSP72) with negligible reactivity with other HSP70 family members (e.g. HSC70/HSP73, Grp78)
  • Higher throughput – measure ~40 samples in duplicate in just 4.5 hours
Substrate loading complex for the HSP90 system [HSP90 (orange), HSP70 (light orange), HSP40 (yellow), HOP (blue), and client substrate (red)
Heat shock mediated induction of [pSer326]HSF1 Protein (Prod. No. ADI-900-199) in HeLa and 3T3 cells. Induction is expressed as the fold change relative to non heat‐shocked control samples.
 

HSP90α (human), ELISA Kit

Most sensitive, rapid ELISA kit for highly specific, quantitative detection of human HSP90α

  • Reproducible – less than 10% variation between assays
  • Sensitive – detect as little as 50 pg/ml of human HSP90α
  • Higher throughput – test up to 40 samples in duplicate in just 3 hours
  • Quantitative – obtain precise, statistically significant results, facilitating comparison of data between multiple experiments

[pSer326]HSF1 ELISA kit

Sensitive, ELISA kit for this key transcription factor for heat shock protein (chaperone) research.

  • Sensitive - measure pg/ml of HSF1 and use less precious sample compared to Western blot
  • Time Saving - results from up to 40 samples in duplicate in just 3 hours
  • Convenient - ready-to-use liquid color-coded reagents and pre-coated plate

Biological Significance of Heat Shock Proteins & Chaperones

The family of heat shock proteins (HSPs) was initially characterized as a highly conserved battery of genes whose expression could be induced by heat shock. HSPs play a prominent role in many of the cell’s most basic processes. Many heat shock protein family members are now known to function constitutively as molecular chaperones, stabilizing and assisting in the trafficking of nascent peptides during normal growth. Under stressful conditions such as heat shock or hypoxia, increased expression of heat shock proteins protects the cell by stabilizing unfolded or misfolded peptides, giving the cell time to repair or re-synthesize damaged proteins. Their general role as molecular chaperones, protectors of the proteome, is now central to many areas of active research including aging, neurodegeneration, signaling, immunology and cancer.

Many heat shock proteins function together in co-chaperone complexes, such as HSP70/HSP40 (bacterial DnaK/DnaJ) that along with GrpE acts as an ATP-regulated shuttle complex for newly synthesized proteins. Many of these nascent peptides are delivered to HSP90-containing complexes, which play a critical role in the stabilization and activation of key signaling kinases and hormone receptors. The HSP60/HSP10 complex (bacterial GroEL/GroES) forms an alternative protein folding mechanism in the mitochondria. Small heat shock proteins including HSP27 and the crystallins form large oligomeric complexes that function to prevent protein aggregation.

Online Reference Tools

  • Heat Shock Protein Gene Table
    Includes links to Entrez & SwissProt entries, and related products

  • Tutorial: Heat Shock Proteins and the Stress Response
    The Hsp basics in a 45 minute narrated slide show

  • Heat shock protein - Wikipedia, the free encyclopedia
    Heat shock proteins (HSPs) are a group of proteins whose expression is increased when the cells are exposed to elevated temperatures or other stress...

  • Chaperone - Wikipedia, the free encyclopedia
    Chaperones are proteins that assist the non-covalent folding/unfolding and the assembly/disassembly of other macromolecular structures,...
 
 

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