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CELLestial Assay Kits for Live Cell Analysis
Selected Literature
CELLestial™ Assay Kits for Live Cell Analysis Catalog
CELLestial Areas of Interest
MitoToxicity
GPCRs
Nuclear Dynamics
Lysosomal Degradation
All CELLestial® dyes and probes
CELLestial FAQs for Kits
Apoptosis & Necrosis
Calcium Mobilization
Cell Cycle
ROS/RNS
Organelles
CELLestial Troubleshooting for Kits
Apoptosis & Necrosis
Calcium Mobilization
Cell Cycle
Cytotoxicity
Organelles
MDR
ROS/RNS
The CELLestial® product line provides a variety of tools to help pharmaceutical and biotech companies optimize their pre-clinical and clinical drug development programs through early lead drug identification, lead candidate selection, predictive toxicology and compound characterization. Overall, these assays may be broadly classified into six main categories:
Death pathway assays
Cell-based assays for monitoring compound effects on apoptosis, autophagy and necrosis. Includes monitoring of annexin V redistribution, nuclear condensation, autophagosome generation and loss of plasma membrane integrity.
Oxidative stress, antioxidants & scavenger assays
Cell-based assays for monitoring compound effects on reactive oxygen species, superoxide, nitric oxide and peroxynitrite.
Organelle detection assays
- ER-ID™ Green assay kit
- ER-ID™ Red assay kit
- Lyso-ID® Red detection kit
- Lyso-ID® Green detection kit
- Mito-ID® Red detection kit
- Mito-ID® Green detection kit
- Nuclear-ID® Blue/Green cell viability reagent
- Nuclear-ID® Blue/Red cell viability reagent
- Nuclear-ID® Red/Green cell viability reagent
- Organelle-ID RGB™ assay III kit
- Organelle-ID RGB™ reagent I
- Organelle-ID RGB™ reagent II
- Organelle-ID RGB™ reagent IV
Cell cycle and transcriptional arrest assays
Cell-based assays for monitoring compound effects on cell cycle dynamics, ribosome biogenesis, inhibition of transcription
Toxicology assays
Cell-based assays for monitoring compound effects on the function and viability of human cell lines. Includes monitoring cell viability, cell proliferation/cytotoxicity, lysosome expansion and mitochondrial activity.
GPCR-Based Drug Discovery
Drugs targeting members of the G protein-coupled receptor (GPCR) super-family account for ~ 40% of all prescription pharmaceuticals on the market today. Calcium assays measure transient calcium mobilization for intracellular stores in response to the activation of Gαq-coupled GPCRs.
Multidrug Resistance
Multidrug resistance relates to resistance of tumor cells to a complete range of chemotherapy drugs with different structures and cellular targets. The phenomenon of multidrug resistance (MDR) is a well-known problem in oncology which necessitates a profound consideration in cancer treatment. The multidrug resistance kits provide fast, sensitive and quantitative method for monitoring the function and expression of the three clinically most important multidrug resistance proteins: MDR1 (P-glycoprotein), MRP1/2 and BCRP.
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