Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Potential Role of USP15 for Cancer Treatment

Cancer is the second leading cause of death globally, and is responsible for 1 in 6 deaths. Many cancers are due to genetic mutations from environmental and life style factors such as diet, tobacco, infection, pollution, and sun exposure. Some cancers are due to inherited genetics. The chance of survival depends on the type of cancer, stage of diagnosis, and the extent of the disease. Screening for early detection and genetic testing can increase the rate of survival. Many treatment options are available including surgery and chemotherapy depending on the type, location and the patients’ health. A recent study proposes a potential new target for treatment of breast and pancreatic cancers.

Stem Cells
Researchers identified USP15, a deubiquitinating enzyme, as playing an important role in maintaining genome stability and tumor suppression. USP15 deletions occur in 16% of breast cancers and 5% of pancreatic cancers. The data suggest that cancer-linked USP15 mutations can increase poly ADP ribose polymerase (PARP) sensitivity in cancer cells. PARP inhibitors are a therapeutic target, especially for patients with cancer, including BRCA mutations. These findings make USP15 a potential biomarker for cancer as it regulates homologous recombination and cancer cell response to PARP inhibitors. Future research is needed to identify potential USP15 inhibitors.
For more information: https://www.nature.com/articles/s41467-019-09232-8

Enzo Life Sciences provides a wide range of products for all your Cancer and Epigenetics research needs. Our platforms provide a wide range of small molecules, antibodies, and proteins including our USP15. The SCREEN-WELL® Cancer Library is a collection of 275 compounds that can be used for cancer inhibitor screening and assay development. Our UBIQAPTURE-Q® Kit and Ubiquitinylation Kit are versatile tools for your ubiquitinylation research needs.

Tags: In The News

Never miss a new TechNote!

Receive our TechNotes as soon as they are published.


 
comments powered by Disqus

Follow Us!

 

Related Products

USP15 (human), (recombinant) (His-tag) 

Produced in E. coli., ≥95% (SDS-PAGE) | Print as PDF
 
BML-UW9845-0100 100 µg 342.00 USD
Do you need bulk/larger quantities?
 

USP15 (human) polyclonal antibody 

WB | Print as PDF
 
BML-PW9795-0025 25 µl 110.00 USD
 
BML-PW9795-0100 100 µl 330.00 USD
Do you need bulk/larger quantities?
 

SCREEN-WELL® Cancer Library 

Essential standards for cancer inhibitor screening
HTS | Print as PDF
 
ENZ-LIB102-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

UBIQAPTURE-Q® kit 

Market-leading tool for isolation and detection of ubiquitinylated proteins.
Print as PDF
 
BML-UW8995-0001 20 tests 484.00 USD
Do you need bulk/larger quantities?
 

Ubiquitinylation kit 

Versatile tool for generation of ubiquitin-E2 thioesters.
Print as PDF
 
BML-UW9920-0001 1 Kit 527.00 USD
Do you need bulk/larger quantities?
 

Mono- and polyubiquitinylated conjugates monoclonal antibody (FK2) 

Gold standard antibody for detection of ubiquitinylated proteins.
Purified from ascites., ELISA, IHC, IP, WB | Print as PDF
 
BML-PW8810-0100 100 µg 154.00 USD
 
BML-PW8810-0500 500 µg 615.00 USD
Do you need bulk/larger quantities?
 

PD-1 (human), (recombinant) 

Produced in HEK cells. Extracellular domain of PD-1 (aa 25-167) containing a 5’-His-tag, V5 epitope tag spacer, and a FLAG-tag., ≥90% (SDS-PAGE) | Print as PDF
 
ENZ-PRT190-0050 50 µg 316.00 USD
Do you need bulk/larger quantities?
 

PD-L1 (human), (recombinant) 

Produced in HEK cells. Human PD-L1 (aa 19-239) is fused at the N-terminus to a His-tag and FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF
 
ENZ-PRT223-0100 100 µg 494.00 USD
Do you need bulk/larger quantities?
 

PARP-1 (catalytic domain) (human), (recombinant) (His-tag) 

Produced in SF21 insect cells. Human PARP-1 (aa 656-1014) is fused to a C-terminal His-tag. Produced in a baculovirus expression system., ≥90% (SDS-PAGE) | Print as PDF
 
ALX-201-232-C020 20 µg 495.00 USD
Do you need bulk/larger quantities?
 

PARP polyclonal antibody 

Whole rabbit serum., ELISA, WB | Print as PDF
 
BML-SA253-0025 25 µl 136.00 USD
 
BML-SA253-0100 100 µl 329.00 USD
Do you need bulk/larger quantities?
 

PARP-1 monoclonal antibody (C-2-10) (affinity purified) 

Purified from ascites., ELISA, ICC, WB | Print as PDF
 
BML-SA249-0050 50 µg 340.00 USD
Do you need bulk/larger quantities?
 

PARP-1 monoclonal antibody (C-2-10) 

Mouse ascites., ELISA, IHC, WB | Print as PDF
 
BML-SA250-0050 50 µl 316.00 USD
Do you need bulk/larger quantities?
 

Blocking peptide for Poly(ADP-ribose) polymerase pAb (Prod. No. BML-SA253) 

≥90% | Print as PDF
 
BML-SP253-0100 100 µg 66.00 USD
Do you need bulk/larger quantities?
 

ABT-888 

PARP inhibitor
912445-05-7, ≥98% (HPLC) | Print as PDF
 
ALX-270-444-M001 1 mg 77.00 USD
 
ALX-270-444-M005 5 mg 165.00 USD
 
ALX-270-444-M025 25 mg 443.00 USD
Do you need bulk/larger quantities?
 

5-AIQ . hydrochloride 

PARP-1 inhibitor
93117-07-8, ≥97% (HPLC) | Print as PDF
 
ALX-270-285-M001 1 mg 59.00 USD
 
ALX-270-285-M005 5 mg 229.00 USD
Do you need bulk/larger quantities?
 

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2019 Enzo Life Sciences, Inc.,