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Heart Hormones Provide Protection Against Obesity

More than one third of Americans are now considered obese. Obesity is a risk factor for metabolic disorders including diabetes and cardiovascular disease. Atrial natriuretic peptide (ANP) and the related B-type NP (BNP) are synthesized in cardiac muscle cells in response to various forms of stress. They are key factors that act on the kidney to control blood pressure. ANP and BNP levels can be used as biomarkers to rule out myocardial infarction. Previous reports have suggested a link between obesity and natriuretic peptides (NPs). Typically, obese patients have fewer NPs circulating and have an increased amounts of NP clearance receptors (NPRCs).

Stem Cells
Researchers suggest that enhancing NP signaling in fat tissue, rather than skeletal muscle, can prevent diet-induced obesity and insulin resistance. Mice were generated with tissue-specific deletion of the NPRC in adipose tissue (NprcAKO) or in skeletal muscle (NprcMKO). The NprcAKO mice were resistant to diet-induced obesity, increased energy expenditure, improved insulin sensitivity and increased glucose uptake into brown fat. Therefore, the NPRC in adipose tissue was determined to be critical for regulating energy metabolism. These findings suggest that enhancing natriuretic peptide signaling in adipose tissue could be a way to combat metabolic disease. Further research is needed to understand the relationship between the difference in fat tissue and peptide signaling to identify therapeutic targets.
For more information: https://www.ncbi.nlm.nih.gov/pubmed/28743802

Enzo Life Sciences provides a wide range of products for all your Cardiovascular and Metabolism needs. Our platforms provide a wide range of small molecules, antibodies, and proteins. Our SCREEN-WELL® Cardiotoxicity Library is a collection of 130 compounds with assorted cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. Additionally, our SCREEN-WELL® Hematopoietic Toxicity Library contains 115 compounds with defined hematopoietic toxicity, including myelosuppression, neutropenia, leukopenia, and anemia.

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