Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

‘Zombie’ Gene Protects Elephants from Cancer

Elephants have surprisingly low rates of cancer for their large size and long lives. Understanding how these animals have lower cancer rates may provide essential information for developing cancer treatments. Humans have one copy of the well-studied anticancer gene, p53, which can sense damaged DNA. Interestingly, elephants have 20 copies of the p53 gene that respond to DNA damage by switching on a unique gene that destroys cells instead of repairing the cell.

In a recent study, a former pseudogene called leukemia inhibitory factor 6 (LIF6), has been identified in the prevention of cancer in elephants. Elephants have eight LIF genes, with LIF6 being the known functional gene. The LIF6 gene makes a protein that creates holes in the mitochondria, the cell's main energy source, causing the cell to die. The report suggests that the LIF6 helps elephants to suppress or eliminate cancer cells, a process that may have led to the increase in size and life span of elephants. Most mammals only have one copy of the LIF gene that have various functions including proliferation of stem cells and fertility enhancement. Further studies are needed to identify additional genes related to the signaling pathways involved in the apoptosis and cell repair pathways.

For more information: https://www.ncbi.nlm.nih.gov/pubmed/30110634

Enzo Life Sciences provides a wide variety of products for your Cancer and Cellular Analysis research needs. Our platforms provide a wide range of small molecules, antibodies, and proteins. We offer a high purity, mouse recombinant LIF protein for you research needs. We also have our SCREEN-WELL® Cancer Library, a collection of 275 compounds that can be used for screening and assay development. Our cell death platform contains comprehensive solutions for apoptosis to monitor programmed cell death from membrane to nucleus. Our GFP-CERTIFIED™ Apoptosis/Necrosis Detection Kit is a multiplex assay that distinguishes between healthy, early apoptotic, late apoptotic and necrotic cells, compatible with GFP and other green fluorescent probes.

Never miss a new TechNote!

Receive our TechNotes as soon as they are published.


 
comments powered by Disqus

Follow Us!

 

Related Products

GFP-CERTIFIED® Apoptosis/Necrosis detection kit 

Multiplex assay that distinguishes between  healthy, early apoptotic, late apoptotic and necrotic cells, compatible with GFP and other green fluorescent probes
Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51002-25 25 assays 160.00 USD
 
ENZ-51002-100 100 assays 378.00 USD
Do you need bulk/larger quantities?
 

p53 (human) ELISA kit 

ELISA | Print as PDF
 
ALX-850-057-KI01 96 wells 691.00 USD
Do you need bulk/larger quantities?
 

LIF (mouse), (recombinant) 

Produced in E. coli., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-201-242-L001 1 ml 1,139.00 USD
Do you need bulk/larger quantities?
 

Bax (human) (58-75), (cell permeable) 

≥95% (HPLC) | Print as PDF
 
ALX-152-028-1 1 Vial 184.00 USD
Do you need bulk/larger quantities?
 

Etoposide 

Topoisomerase inhibitor. p53 activator.
33419-42-0, Semisynthetic derivative of podophyllotoxin., ≥95% (HPLC) | Print as PDF
 
BML-GR307-0100 100 mg 90.00 USD
 
BML-GR307-0500 500 mg 356.00 USD
Do you need bulk/larger quantities?
 

CP-31398 

p53 activator
259199-65-0, Synthetic., ≥98% (TLC) | Print as PDF
 
BML-GR360-0010 10 mg 114.00 USD
 
BML-GR360-0050 50 mg 456.00 USD
Do you need bulk/larger quantities?
 

p53 (human) polyclonal antibody 

IHC (PS) | Print as PDF
 
ENZ-ABS195-1000 1 ml 772.00 USD
Do you need bulk/larger quantities?
 

p53 (wild type) (human), (recombinant) 

Produced in E. coli., ≥90% (SDS-PAGE), ELISA, WB, Inhibition assay | Print as PDF
 
ADI-908-265-010 10 µg 512.00 USD
Do you need bulk/larger quantities?
 

p53 Recombinant monoclonal antibody (PAb421) (Mouse IgG2aκ) 

ELISA, IF, IHC (FS), IHC (PS), IP, WB | Print as PDF
 
ENZ-ABS653-0200 200 µg 440.00 USD
Do you need bulk/larger quantities?
 

(S)-(+)-Camptothecin 

Potent antitumor agent
7689-03-4, Isolated from Mappia foetida Miers (Nothapodytes foetida (Wt.) Sleumer)., ≥98% (HPLC) | Print as PDF
 
ALX-350-015-M050 50 mg 54.00 USD
 
ALX-350-015-M250 250 mg 186.00 USD
 
ALX-350-015-G001 1 g 405.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Blue/Green cell viability reagent 

Distinguishes between live vs dead cells in a single reagent.
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53004-C100 100 µl 250.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Blue/Red cell viability reagent (GFP-CERTIFIED®) 

Distinguishes between live vs dead cells in a single reagent.
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53005-C100 100 µl 245.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Red/Green cell viability reagent 

Distinguishes between live vs dead cells in a single reagent
≥93% (HPLC), Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-53006-C100 100 µl 250.00 USD
Do you need bulk/larger quantities?
 

Pifithrin-α 

p53 inhibitor
63208-82-2, ≥98% (TLC) | Print as PDF
 
BML-GR325-0005 5 mg 77.00 USD
 
BML-GR325-0025 25 mg 323.00 USD
Do you need bulk/larger quantities?
 

Pifithrin-α (cyclic) . hydrobromide 

p53 inhibitor
60477-34-1, ≥95% (HPLC, TLC) | Print as PDF
 
ALX-270-287-M010 10 mg 166.00 USD
 
ALX-270-287-M050 50 mg 685.00 USD
Do you need bulk/larger quantities?
 

IMMUNOSET® p53/MDM2 complex ELISA development set 

First ELISA development product for the measurement of the p53/MDM2 complex for apoptosis and autophagy research.
ELISA, Colorimetric detection | Print as PDF
 
ADI-960-070 5x96 wells 525.00 USD
Do you need bulk/larger quantities?
 

p53 activator 

p53 activator
≥97% (HPLC) | Print as PDF
 
BML-P603-0500 0.5 mg 246.00 USD
Do you need bulk/larger quantities?
 

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2018 Enzo Life Sciences, Inc.,