Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Nucleolus Size Determines Life Span

A structure inside our cells, called the nucleolus, is well known as the site of ribosome biogenesis. Ribosomes are essential for protein synthesis, a process known as translation. The nucleolus functions in many cellular processes and has a prominent role in the stress response, development, and aging. Perturbations in nucleolar function have been associated with cancer and progeria, a rare genetic premature aging disorder. The highly dynamic organelle can assess cellular performance and balance the production of protein synthesis. The relationship between nucleolar function and size with aging is an intriguing area of research.

A recent review highlighted nucleolar function in development and lifespan regulation. The nucleolus can respond to growth signals and nutrients. When the metabolic pathway is reduced, the nucleoli shrink, make fewer ribosomes, and cells were observed to live longer. The research suggests that modest dietary restriction and exercise could shrink the nucleoli in muscle cells of patients over 60. Conversely, cancer patients and patients with accelerated aging diseases, tend to have larger nucleoli. Life span could be determined by how well the nucleolus balances the need to grow with the need to repair. Therefore, the size of the nucleoli could be used as a cellular hallmark for aging. Further studies are needed to see if the nucleoli size changes are actually the cause of aging. Understanding the molecular mechanisms involved in longevity and aging diseases could lead to treatment and extended life spans.

For more information: https://www.cell.com/trends/cell-biology/fulltext/S0962-8924(18)30063-1

Enzo Life Sciences’ NUCLEOLAR-ID® Green Detection Kit contains a proprietary dye suitable for live-cell staining of nucleoli. The dye allows examination of nucleolar dynamic changes in intracellular distribution, trafficking and localization arising from biological processes such as the cell cycle and ribosome biogenesis. The kit is compatible with most fluorescence detection systems, including conventional and confocal fluorescence microscopes, as well as High Content Screening (HCS) platforms. Additionally, our TOTAL-NUCLEAR-ID® Green/Red Nucleolar/Nuclear Detection Kit contains two proprietary dyes suitable for simultaneous live-cell staining of nucleoli and nuclei.

Tags: In The News

Never miss a new TechNote!

Receive our TechNotes as soon as they are published.


Featured Literature

Brochures
Live Cell Analysis
 
comments powered by Disqus

Follow Us!

 

Related Products

NUCLEOLAR-ID® Green detection kit  

Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51009-500 1 Kit 183.00 USD
Do you need bulk/larger quantities?
 

TOTAL-NUCLEAR-ID® green/red nucleolar/nuclear detection kit  

Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51006-500 1 Kit 250.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Red cell cycle kit (GFP-CERTIFIED®) 

Convenient kit for studying cell cycle progression by various applications
Flow Cytometry, Fluorescence microscopy | Print as PDF
 
ENZ-51008-100 1 Kit 327.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Green cell cycle kit  

Cell Cycle Results Independent of Incubation Time, Temperature, Dye and Cell Concentrations
Flow Cytometry, Fluorescence microscopy | Print as PDF
 
ENZ-51014-100 1 Kit 318.00 USD
Do you need bulk/larger quantities?
 

Rapamycin 

Immunosuppressant
53123-88-9, ≥98% (HPLC) | Print as PDF
 
BML-A275-0005 5 mg 82.00 USD
 
BML-A275-0025 25 mg 260.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Red DNA stain 

Cell permeable DNA stain that can be used for a wide range of applications
≥93% (HPLC), Flow Cytometry, Fluorescent detection | Print as PDF
 
ENZ-52406 200 µl 332.00 USD
Do you need bulk/larger quantities?
 

NUCLEAR-ID® Blue DNA stain (GFP-CERTIFIED®) 

Cell permeable DNA stain that can be used for a wide range of applications
≥95% (HPLC), Flow Cytometry, Fluorescent detection | Print as PDF
 
ENZ-CHM103-0200 200 µl 205.00 USD
Do you need bulk/larger quantities?
 

ORGANELLE-ID-RGB® III assay kit 

Mixture of fluorescent dyes for detection of  endoplasmic reticulum, Golgi apparatus and nucleus
Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51032-K100 1 Kit 349.00 USD
Do you need bulk/larger quantities?
 

MITO-ID® Green detection kit  

Photostable,  non-toxic and selective mitochondrial dye that stains regardless of membrane potential
Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51022-0100 100 tests 87.00 USD
 
ENZ-51022-K500 500 tests 241.00 USD
Do you need bulk/larger quantities?
 

LYSO-ID® Green detection kit  

Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51034-0100 100 tests 89.00 USD
 
ENZ-51034-K500 500 tests 240.00 USD
Do you need bulk/larger quantities?
 

GOLGI ID® Green assay kit 

Dependably  localizes to Golgi apparatus with minimal staining of ER
Fluorescence microscopy | Print as PDF
 
ENZ-51028-K100 1 Kit 236.00 USD
Do you need bulk/larger quantities?
 

ORGANELLE-ID-RGB® reagent I 

Mixture of fluorescent dyes for detection of lysosomes, mitochondria and nucleic acids
≥93% (HPLC) | Print as PDF
 
ENZ-53007-C200 200 µl 347.00 USD
Do you need bulk/larger quantities?
 

ORGANELLE-ID-RGB® reagent II 

Mixture of fluorescent dyes for detection of lysosomes, endoplasmic reticulum and nucleic acids
≥93% (HPLC) | Print as PDF
 
ENZ-53008-C200 200 µl 347.00 USD
Do you need bulk/larger quantities?
 

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2018 Enzo Life Sciences, Inc.,