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Stress Might Make You Sick

In response to immediate danger, stress can initiate a fight-or-flight response that can lead to the release of cortisol, increased blood sugar levels, and reduced inflammation. However, high stress levels over a longer time period can increase the risk of diseases including heart problems, allergic reactions, asthma, and irritable bowel syndrome (IBS). Many people meditate, sleep, and exercise more to reduce the harmful effects of stress. A recent study investigates the effect of stress on the immune system to identify key therapeutic targets that could also help reduce stress-related diseases.

Corticotropin-releasing factor (CRF-1), a stress receptor, can activate mast cells, after which the immune response is initiated. However, long term stress can cause CRF-1 to stimulate inflammatory and allergic diseases such as asthma, food allergies, IBS, and autoimmune disorders. Histamine is known not only for helping clear allergens from the body, but also for initiating allergic reactions. A similar response can be seen to severe allergy and high stress. A comparison of histamine responses of mice with or without CRF-1 under two different types of stress, psychological and allergic, were monitored. The data suggests that CRF-1 is critical for the risk and development of diseases initiated by stress. By identifying how stress can make us sick, potential new drug targets could help treat asthma, IBS, and other common stress-related diseases.

For more information: http://msutoday.msu.edu/news/2018/heres-how-stress-may-be-making-you-sick/

Enzo offers hundreds of immunoassay and enzyme activity assay kits in a variety of formats to service the biomarker and drug discovery assay markets. Our platforms provide a range of small molecules, antibodies, and proteins. Our SCREEN-WELL® Histaminergic ligand library contains 41 ligands including endogenous neurotransmitters, agonists, antagonists, and marketed drugs. The library is ideal for screening or identifying recombinant orphan G protein coupled receptors, target validation, secondary screening, assay development, and other pharmacological applications. Our widely used sensitive Cortisol ELISA kit can be used with a larger variety of sample types and yield highly reproducible results for stress, autoimmune disease, and cancer research. Our ultra-sensitive Histamine ELISA kit enables detection of histamine in serum, plasma, urine, and tissue culture media in just 2 hours!

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