Obesity is a disorder involving excessive body fat and it is the leading preventable cause of death worldwide. Lack of physical activity and excessive food intake can cause obesity and lead to various diseases such as cardiovascular disease, diabetes, and cancer. Lifestyle changes including, diet and exercise, are common ways to treat obesity. The most effective obesity treatment is surgery, but it can be risky and expensive. Researchers are trying to develop other effective and less invasive treatments and therapeutics, especially with the number of adult and childhood obesity cases on the rise.
In a recent publication, the regulator of Calcineurin 1 (RCAN1) was identified as a potential target for combating obesity. RCAN1 is a feedback inhibitor of the calcium‐activated protein phosphatase calcineurin and can suppress two different mechanisms of non‐shivering thermogenesis in white fat and skeletal muscle. Previous studies have targeted mechanisms to burn excess calories as heat rather than store the calories as fat. The data suggests that mice deficient for Rcan1 have an increased metabolic rate and are resistant to diet‐induced obesity. Further studies are needed to determine if targeting RCAN1 can also be effective in humans. Therapeutic development by targeting RCAN1 to burn more calories at rest and store less fat without the need to reduce food consumption or exercise would help combat obesity.
For more information: https://www.ncbi.nlm.nih.gov/pubmed/30389725
Produced in E. coli. Human calcineurin Aα (MW 60kDa) and calcineurin B (MW 15kDa) heterodimer. Both subunits are coexpressed in a construct with yeast myristoyl-CoA:protein N-myristoyltransferase. The resulting highly active calcineurin (protein phosphatase 2B) is N-myristoylated on the CaNB subunit, similar to the native protein., ≥90% (SDS-PAGE) | Print as PDF
Homeostatic factor for regulating glucose levels, lipid metabolism, and insulin sensitivity
Produced in HEK 293 cells. Human adiponectin (aa 16-244) is fused at the N-terminus to a linker peptide (14 aa) and a FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF
Ultra-sensitive AMP'D® GLP-1 ELISA kit enabling the ability to use less sample to detect levels of human Glucagon-like peptide 1 (7-36) amide, a potent promoter of insulin secretion, a major incretin hormone, and therapeutic for type 2 diabetes.