Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Parkinson’s Disease Linked With Autoimmunity

Parkinson’s disease (PD) is a degenerative disorder that mainly affects the motor system. Symptoms include shaking, slow movement, and difficulty walking. Diagnosis usually occurs in people over 60 but early onset PD can occur in patients with a shortened life expectancy. In advanced stages, depression and dementia are also associated with the disease. The cause of Parkinson’s is believed to be both genetic and environmental and there is no known cure. PD involves the death of vital neurons in the brain. Some of these neurons produce dopamine which is essential for movement and coordination. As PD progresses, the amount of dopamine decreases. Initial treatment is typically with L-DOPA, to increase dopamine levels, and diet and exercise may also improve symptoms. We previously reported on the modulation of NAD+ levels leading to neuroprotective effects in a model of Parkinson’s disease.

A recent study has suggested PD could be an autoimmune disorder. This occurs when the immune system attacks its own tissue. In PD patients, neurons can become filled with lewy bodies, which are composed of misfolded alpha-synuclein proteins associated with ubiquitin, and alpha B cystallin or tau. In this study, two fragments of alpha-synuclein were added to blood samples from people diagnosed with Parkinson’s disease. The two fragments of the alpha-synuclein stimulated a strong T cell immune response. This suggests that the T cells have been primed to recognize the alpha-synuclein from previous exposure. Further studies are needed to determine if the immune response to alpha-synuclein causes PD or if it contributes to the symptoms of PD. The molecular pathways that lead to an immune response need to be identified. This study may be used to identify people at risk or early onset of the disease. Additionally, new drugs that prevent neural death that resemble other autoimmune disease treatments may be developed.

For more information: https://www.ncbi.nlm.nih.gov/pubmed/28636593

Enzo Life Sciences provides a wide variety of products for your Neuroscience and Immunology research needs. Our PROTEOSTAT® Protein aggregation assay provides a simple, homogeneous assay format for monitoring peptide and protein aggregation in solution. The Enzo PROTEOSTAT® detection reagent can detect aggregates from a broader range of proteins, yields a much brighter signal, provides at least 2 orders of magnitude linear dynamic range and offers superior performance across a broad range of pH values (4~10) and buffer compositions. Sensitivity for this assay is in the sub-micromolar range and as little as 1-5% protein aggregate is detectable in a concentrated protein solution.

Never miss a new TechNote!

Receive our TechNotes as soon as they are published.


 
comments powered by Disqus

follow Us!

 

Related Products

α-Synuclein (human), (recombinant) 

Produced in E. coli., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-201-265-C100 100 µg 273.00 USD
Do you need bulk/larger quantities?
 

Synuclein α polyclonal antibody 

IHC | Print as PDF
 
ADI-905-565-1 1 ml 350.00 USD
Do you need bulk/larger quantities?
 

PROTEOSTAT® Thermal shift stability assay kit 

Accelerated screening for protein stability as a function of pH,  ionic strength, and concentration.
Print as PDF
 
ENZ-51027-K100 100 tests 179.00 USD
 
ENZ-51027-K400 400 tests 476.00 USD
Do you need bulk/larger quantities?
 

PROTEOSTAT® Protein refolding and aggregation sensing kit  

Identify Optimal Protein Refolding Conditions and Maximize Recovery of Functional Protein
Print as PDF
 
ENZ-51040-KP002 2x96 wells 367.00 USD
Do you need bulk/larger quantities?
 

PROTEOSTAT® PDI assay kit 

Fluorescent detection | Print as PDF
 
ENZ-51024-KP050 50 tests 201.00 USD
 
ENZ-51024-KP002 2x96 tests 536.00 USD
Do you need bulk/larger quantities?
 

PROTEOSTAT® Aggresome detection kit  

Robust, quantitative detection of aggresomes relevant to the study of neurodegenerative disease, liver disease and  toxicology
Flow Cytometry, Fluorescence microscopy, Fluorescent detection | Print as PDF
 
ENZ-51035-0025 25 tests 108.00 USD
 
ENZ-51035-K100 100 tests 294.00 USD
Do you need bulk/larger quantities?
 

PROTEOSTAT® Protein aggregation standards  

The only commercially available protein aggregation standards assay!
Fluorescent detection, Microplate | Print as PDF
 
ENZ-51039-KP002 2x96 wells 208.00 USD
Do you need bulk/larger quantities?
 

PROTEOSTAT® Thioredoxin-1 assay kit  

Fluorescent detection | Print as PDF
 
ENZ-51033-KP002 2x96 wells 549.00 USD
Do you need bulk/larger quantities?
 

PD-1 (human), (recombinant) 

Produced in HEK cells. Extracellular domain of PD-1 (aa 25-167) containing a 5’-His-tag, V5 epitope tag spacer, and a FLAG-tag., ≥90% (SDS-PAGE) | Print as PDF
 
ENZ-PRT190-0050 50 µg 301.00 USD
 

PD-L1 (human), (recombinant) 

Produced in HEK cells. Human PD-L1 (aa 19-239) is fused at the N-terminus to a His-tag and FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF
 
ENZ-PRT223-0100 100 µg 350.00 USD
Do you need bulk/larger quantities?
 

MEGACD40L® (soluble) (human), (recombinant) 

High activity, high purity CD40L protein for co-stimulatory activation of an immune response
Produced in CHO cells. The extracellular domain of human CD40L (CD154) (aa 116-261) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag., ≥90% (SDS-PAGE) | Print as PDF
 
ALX-522-110-C010 10 µg 499.00 USD
Do you need bulk/larger quantities?
 

MEGACD40L® (soluble) (mouse), (recombinant) 

Highly active
Produced in CHO cells. The extracellular domain of mouse CD40L (CD154) (aa 115-260) is fused at the N-terminus to mouse ACRP30headless (aa 18-111) and a FLAG®-tag., ≥95% (SDS-PAGE) | Print as PDF
 
ALX-522-120-C010 10 µg 525.00 USD
Do you need bulk/larger quantities?
 

Dopamine-β-hydroxylase polyclonal antibody 

IHC, WB | Print as PDF
 
BML-DZ1020-0050 50 µl 378.00 USD
Do you need bulk/larger quantities?
 

Dopamine polyclonal antibody 

ELISA, IHC | Print as PDF
 
BML-DA1140-0025 25 µl 100.00 USD
Do you need bulk/larger quantities?
 

Dopamine transporter (extracellular loop) polyclonal antibody 

IHC, WB | Print as PDF
 
BML-SA509-0100 100 µl 367.00 USD
Do you need bulk/larger quantities?
 

AJ-76 

Dopamine receptor ligand
85379-09-5, ≥98% (HPLC) | Print as PDF
 
BML-D101-0010 10 mg 177.00 USD
Do you need bulk/larger quantities?
 

Bromocriptine . mesylate 

Dopamine receptor ligand
22260-51-1, ≥98% (HPLC) | Print as PDF
 
BML-D102-0100 100 mg 78.00 USD
 
BML-D102-0500 500 mg 318.00 USD
Do you need bulk/larger quantities?
 

BTCP 

Dopamine receptor inhibitor
112726-66-6, ≥98% (HPLC) | Print as PDF
 
BML-D103-0010 10 mg 211.00 USD
Do you need bulk/larger quantities?
 

Bupropion . HCl 

Inhibitor of dopamine and norepinephrine transporters
31677-93-7, ≥98% (TLC) | Print as PDF
 
BML-NS111-0050 50 mg 70.00 USD
 
BML-NS111-0250 250 mg 296.00 USD
Do you need bulk/larger quantities?
 

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,