Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Are Cancer Mutations Due to Random DNA Copying Mistakes?

Many cancer causing mutations are attributed to inheritance and environmental factors. Errors associated with DNA replication may also play a prominent role in cancer development. There are opportunities for DNA replication mistakes at every cell division. These mutations can accumulate and cause uncontrolled cell division that can lead to cancer development. Cancer is more common in tissues that divide often. For example, colon cells divide more frequently and are likely to introduce random DNA replication mistakes. In contrast, lung cancer is more likely associated with mutations influenced by environmental factors, making it less prevalent. As we age, the risk of cancer due to random DNA replication mistakes may increase.

A previous publication made a claim that cancer was due to “bad luck”. Recently, a follow-up study also suggested that cancer risk is most strongly associated with how fast stem cells replicate. This can lead to random genetic mistakes that occur in dividing cells that may lead to cancer. Using existing data, 32 types of cancer from patients in 69 countries were analyzed. Two-thirds of the cancer mutations were associated with random DNA replication mistakes.

Many factors can influence the development and progression of cancer. It is difficult to comprehend the complicated nature of cancer and identify a single cause. However, further research on chance genetic mistakes is needed to help better understand its development. Environmental exposure, lifestyle and inherited risk are also important as many cancers may still be preventable. This new understanding of the role of random DNA mutations may lead to an increased focus on improving detection methods to identify early stages of cancer development.

For more information: http://science.sciencemag.org/content/355/6331/1330

Enzo Life Sciences provides a wide variety of products for your Cancer and Genomics research needs. We offer an extensive portfolio including labeling and detection kits, substrates, active proteins, antibodies and inhibitors. Our SCREEN-WELL® Cancer Library, is a collection of 275 compounds that can be used for screening and assay development. The library contains small molecule inhibitors that affect mTOR, aurora kinases, tyrosine kinases, PI3K, and HDAC, as well as many other structurally and mechanically different compound classes. The SCREEN-WELL® Cancer Library is an essential tool for drug development and cancer inhibitor screening.

Never miss a new TechNote!

Receive our TechNotes as soon as they are published.


 
comments powered by Disqus

follow Us!

 

Related Products

CYTAG® TotalCGH Labeling kit 

Complete kit to digest and label DNA for CGH+SNP arrays
CGH | Print as PDF
 
ENZ-42674-0010 2x10 Reactions Inquire for pricing
 
ENZ-42674-0100 2x100 Reactions Inquire for pricing
Do you need bulk/larger quantities?
 

CYTAG® CGH Labeling kit 

Superior labeling efficiency and better dye incorporation results in less failed runs
CGH | Print as PDF
 
ENZ-42671-K010 2x10 Reactions Inquire for pricing
 
ENZ-42671-K100 2x100 Reactions Inquire for pricing
Do you need bulk/larger quantities?
 

PCR & Gel Clean-up Kit 

Quick, easy kit for purifying DNA from PCR, gels and labeling reactions for a variety of downstream applications.
Print as PDF
 
ENZ-GEN100-0020 20 tests 46.00 USD
 
ENZ-GEN100-0050 50 tests 87.00 USD
 
ENZ-GEN100-0200 200 tests 301.00 USD
Do you need bulk/larger quantities?
 

Nick translation DNA labeling system 2.0 

Nick translation system for preparing FISH probes
ISH (in situ hybridization), FISH | Print as PDF
 
ENZ-GEN111-0050 50 tests 260.00 USD
Do you need bulk/larger quantities?
 

SCREEN-WELL® Kinase Inhibitor library 

HTS | Print as PDF
 
BML-2832-0500 1 Library 500 µl/well Inquire for pricing
 
BML-2832-0100 1 Library 100 µl/well Inquire for pricing
Do you need bulk/larger quantities?
 

FLOWSCRIPT® HPV E6/E7 assay kit 

Flow cytometry-based assay for the single cell detection of mRNAs for HPV oncoproteins E6 and E7
Flow Cytometry, Fluorescent detection | Print as PDF
 
ENZ-GEN300-0100 100 tests Inquire for pricing
Do you need bulk/larger quantities?
 

FLOWSCRIPT® HPV E6/E7 positive control cells 

Positive control cells for the FLOWSCRIPT® HPV E6/E7 assay kit
Flow Cytometry | Print as PDF
 
ENZ-GEN301-0004 4 ml Inquire for pricing
Do you need bulk/larger quantities?
 

FLOWSCRIPT® HPV E6/E7 negative control cells 

Negative control cells for the FLOWSCRIPT® HPV E6/E7 assay kit
Flow Cytometry | Print as PDF
 
ENZ-GEN302-0004 4 ml Inquire for pricing
Do you need bulk/larger quantities?
 

Human Cot DNA 

Blocks repetitive sequences to prevent nonspecific binding.
ISH (in situ hybridization), Microarray, Southern Blot, FISH, CGH | Print as PDF
 
ENZ-GEN116-0500 500 µg 200.00 USD
Do you need bulk/larger quantities?
 

Human Genomic DNA, Female 

A normal pool of female genomic DNA that can serve as a standard in molecular biology applications
PCR, Southern Blot, CGH | Print as PDF
 
ENZ-GEN118-0100 100 µg 160.00 USD
Do you need bulk/larger quantities?
 

Human Genomic DNA, Male 

A normal pool of male genomic DNA that can serve as a standard in molecular biology applications
PCR, Southern Blot, CGH | Print as PDF
 
ENZ-GEN117-0100 100 µg 160.00 USD
Do you need bulk/larger quantities?
 

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,