Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

ROS implicated in diabetes-associated platelet hyperactivity

Reactive oxygen species (ROS) produced endogenously or in response to an environmental stress have long been associated with a variety of tissue injuries such as ischemic heart disease and stroke. Cells exposed to that form of stress can either respond via different defense mechanisms or die by necrosis or apoptosis. At low levels, however, ROS act as signaling molecules in several intracellular processes and can, for example, increase cytosolic Ca2+ to the level required for activating platelets (Miyata et al., 2011). In their publication in the American Journal of Physiology and Cell Physiology, Dr. Wai Ho Tang and colleagues from Yale University School of Medicine demonstrated that human platelet aggregation and activation are sensitive to glucose concentration, and that aldose reductase contributes to this aggregation under both normal and high glucose conditions through generation of ROS (measured using Enzo’s Total ROS/Superoxide detection kit), phosphorylation of PKC isoforms and p38α MAPK, and release of thromboxane. Looking further into this pathway, urine samples from patients with platelet activation showed increased levels of 11-dehydro-TXB2, a thromboxane metabolite. Interestingly, this increase was even more substantial in diabetic patients. These results demonstrated that a complex regulatory pathway involving oxidative stress plays an important role in thromboxane-induced platelet hyperactivity and that therapies targeting aldose reductase may go a long way toward a better management of cardiovascular events.

Enzo Life Sciences offers oxidative stress researchers a comprehensive range of products including detection kits, ELISA kits and enzyme assays; some of which are described below:

 

References:

Related Products

Glutathione (GSSG/GSH), detection kit 

Rapid, ultra-sensitive kit for the quantification of reduced (GSH), oxidized (GSSG), and total glutathione for oxidative stress research.
Colorimetric detection | Print as PDF
 
ADI-900-160 4x96 wells 422.00 USD
Do you need bulk/larger quantities?
 

Hydrogen peroxide fluorometric detection kit 

Fluorescent detection, HTS | Print as PDF
 
ADI-907-028 500 tests 375.00 USD
Do you need bulk/larger quantities?
 

Nitric Oxide (total), detection kit 

Colorimetric detection | Print as PDF
 
ADI-917-020 2x96 wells 253.00 USD
Do you need bulk/larger quantities?
 

ROS-ID® Superoxide detection kit 

Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51012 1 Kit 180.00 USD
Do you need bulk/larger quantities?
 

ROS-ID® Total ROS detection kit 

Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51011 1 Kit 176.00 USD
Do you need bulk/larger quantities?
 

ROS-ID® Total ROS/Superoxide detection kit 

Directly Monitor Global Levels  of Reactive Oxygen Species (ROS), and Specifically Superoxide
Flow Cytometry, Fluorescence microscopy, Fluorescent detection, HTS | Print as PDF
 
ENZ-51010 1 Kit 247.00 USD
Do you need bulk/larger quantities?
 

DNA damage ELISA kit 

Rapid DNA damage ELISA kit for cancer, apoptosis and oxidative stress.
ELISA, Colorimetric detection | Print as PDF
 
ADI-EKS-350 96 wells 765.00 USD
Do you need bulk/larger quantities?
 

12(S)-HETE ELISA kit 

Sensitive ELISA kit enabling detection of 12(S)-HETE in culture supernatants and plasma from any species.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-050 96 wells 447.00 USD
Do you need bulk/larger quantities?
 

15(S)-HETE ELISA kit 

ELISA, Colorimetric detection | Print as PDF
 
ADI-900-051 96 wells 366.00 USD
Do you need bulk/larger quantities?
 

HO-1 (human), ELISA kit 

Highly sensitive HO-1 ELISA kit enabling detection of HO-1 in cell lysates and tissue extracts in < 2.5 hours.
ELISA, Colorimetric detection | Print as PDF
 
ADI-EKS-800 96 wells 648.00 USD
Do you need bulk/larger quantities?
 

Direct 8-iso-PGF ELISA kit 

Highly sensititive ELISA, measuring 8-iso-Prostaglandin F in plasma, serum and tissue.
ELISA, Colorimetric detection | Print as PDF
 
ADI-900-091 96 wells 390.00 USD
Do you need bulk/larger quantities?
 

11-dehydro-TXB2 ELISA kit 

ELISA, Colorimetric detection | Print as PDF
 
ADI-900-092 96 wells 366.00 USD
Do you need bulk/larger quantities?
 

TXB2 ELISA kit 

ELISA, Colorimetric detection | Print as PDF
 
ADI-900-002 96 wells 350.00 USD
Do you need bulk/larger quantities?
 

Catalase fluorometric detection kit 

Fluorescent detection, HTS | Print as PDF
 
ADI-907-027 500 tests 368.00 USD
Do you need bulk/larger quantities?
 

Glutathione peroxidase activity kit 

Colorimetric detection, Activity assay | Print as PDF
 
ADI-900-158 5x96 wells 615.00 USD
Do you need bulk/larger quantities?
 

Glutathione reductase activity kit 

Colorimetric detection, Activity assay | Print as PDF
 
ADI-900-159 5x96 wells 596.00 USD
Do you need bulk/larger quantities?
 

SOD activity kit 

ELS offers a large collection of superoxide dismutase products for oxidative stress research.
Colorimetric detection, Activity assay | Print as PDF
 
ADI-900-157 5x96 wells 585.00 USD
Do you need bulk/larger quantities?
 

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2019 Enzo Life Sciences, Inc.,