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Caspase-6: A Potential Therapeutic Target for Neurodegenerative Disease

Caspase-6, a member of the cysteine protease family, is well characterized for its role in programmed cell death (PCD), where it acts primarily as an executioner caspase. Many studies, as recently reviewed by Graham et. al. in Trends in Neurosciences, have revealed Caspase-6 as a possible contributor to neurodegenerative pathology associated with Huntington’s Disease (HD), Alzheimer’s Disease (AD), aging, and stroke. Although the mechanisms behind the role of caspase-6 mediated neurodegeneration are still being defined, evidence suggests activation of caspase-6, and resulting cleavage of defined caspase-6 substrates such as Huntingtin, Amyloid Precursor Protein (APP), Tau, CBP/p300, NF-kB, and Caspase-8, make inhibition of caspase-6 an intriguing therapeutic target for neurodegenerative disease.

Enzo Life Sciences offers a wide range of products for Caspase-6 research, including high-purity active recombinant enzymes, substrates, and inhibitors.

 

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Caspase-6 (human), (recombinant) 

Highly, active caspase-6 for the study of enzyme kinetics or screening of inhibitors
Produced in E. coli., ≥80% (SDS-PAGE) | Print as PDF
 
BML-SE170-5000 5000 U 409.00 USD
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Ac-VEID-AFC 

Caspase-6 inhibitor
≥98% (HPLC) | Print as PDF
 
ALX-260-111-M005 5 mg 179.00 USD
 
ALX-260-111-M010 10 mg 281.00 USD
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Ac-VEID-CHO 

Inhibitor of caspase-6, -8 and -10
≥95% (HPLC) | Print as PDF
 
ALX-260-062-M001 1 mg 106.00 USD
 
ALX-260-062-M005 5 mg 412.00 USD
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Z-VE(OMe)ID(OMe)-FMK 

Caspase-6 inhibitor
≥95% (TLC) | Print as PDF
 
ALX-260-075-M001 1 mg 270.00 USD
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Z-VEID-FMK (Ready-to-Use) 

Caspase-6 inhibitor
≥98% (HPLC) | Print as PDF
 
ALX-260-143-R100 100 µl 2mM 189.00 USD
 
ALX-260-143-R020 20 µl 10mM 189.00 USD
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Ac-AAVALLPAVLLALLAPDEVD-CHO 

Caspase inhibitor
≥95% (HPLC) | Print as PDF
 
ALX-260-046-M001 1 mg 89.00 USD
 
ALX-260-046-M005 5 mg 367.00 USD
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Ac-AEVD-CHO 

Inhibitor of caspase-6, -8 and -10
Print as PDF
 
ALX-260-158-M001 1 mg 135.00 USD
 
ALX-260-158-M005 5 mg 203.00 USD
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Ac-IETD-CHO 

Caspase and granzyme inhibitor
191338-86-0, ≥96% (HPLC) | Print as PDF
 
ALX-260-043-M001 1 mg 79.00 USD
 
ALX-260-043-M005 5 mg 308.00 USD
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Ac-VEID-pNA 

Caspase substrate
Synthetic., ≥95% (HPLC) | Print as PDF
 
BML-P437-0005 5 mg 120.00 USD
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Ac-VEID-AMC 

Caspase-6 substrate
219137-97-0, ≥95% (HPLC) | Print as PDF
 
ALX-260-064-M001 1 mg 83.00 USD
 
ALX-260-064-M005 5 mg 142.00 USD
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Ac-IETD-pNA 

Caspase and granzyme substrate
≥98% (HPLC) | Print as PDF
 
ALX-260-045-M001 1 mg 99.00 USD
 
ALX-260-045-M005 5 mg 117.00 USD
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Ac-IETD-AMC 

Caspase and granzyme substrate
≥97% (HPLC) | Print as PDF
 
ALX-260-042-M001 1 mg 48.00 USD
 
ALX-260-042-M005 5 mg 152.00 USD
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