| Alternative Name: | Interleukin-19 |
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| MW: | ~17.7 kDa |
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| Source: | Produced in E. coli. Contains 153 amino acids. |
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| UniProt ID: | Q8CJ70 |
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| Formulation: | Lyophilized from a sterile (0.2 micron) filtered solution containing 10 mM sodium phosphate and 50 mM sodium chloride, pH 7.5. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | ≤1 EU/µg protein (LAL test) |
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| Reconstitution: | Reconstitute in sterile water at 0.1 mg/mL. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
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| Scientific Background: | Interleukin-19 (IL-19) is produced by B cells and monocytes. IL-19 binds the interleukin 20 receptor complex to activate STAT3 signaling. IL-19 induces IL-6 and tumor necrosis factor alpha (TNF-α) expression in monocytes, and promotes T helper 2 cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS) stimulation. |
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| Regulatory Status: | RUO - Research Use Only |
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