| Alternative Name: | Interleukin-11, AGIF, Adipogenesis Inhibitory Factor, Oprelvekin |
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| MW: | ~19.3 kDa |
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| Source: | Produced in E. coli. Contains 179 amino acids. |
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| UniProt ID: | P47873 |
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| Formulation: | Lyophilized from a sterile (0.2 micron) filtered solution containing 0.1% Trifluoroacetic Acid (TFA). |
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| Purity: | ≥95% (SDS-PAGE) |
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| Endotoxin Content: | ≤1 EU/µg protein (LAL test) |
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| Biological Activity: | T11 cell proliferation; ED50 ≤ 2.5 ng/mL (≥ 4.0 x 105 units/mg). |
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| Reconstitution: | Reconstitute in sterile water at 0.1 mg/mL. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -80°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
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| Scientific Background: | Interleukin 11 (IL-11) is a member of the gp130 family of cytokines. IL-11 functions to promote hematopoietic stem cell proliferation and megakaryocyte differentiation. IL-11 binds the IL-11Rα receptor to activate JAK downstream signaling. In non-hematopoietic cell populations, IL-11 stimulates acute-phase proteins, modulates the development of immunoglobulin-producing B cells, and regulates bone turnover. |
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| Regulatory Status: | RUO - Research Use Only |
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