| Alternative Name: | Interferon-γ |
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| MW: | ~16.8 kDa |
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| Source: | Produced in E.coli. |
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| UniProt ID: | P01579 |
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| Formulation: | Lyophilized from 10mM sodium phosphate, pH 7.4. |
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| Purity: | ≥98% (SDS-PAGE gel & HPLC) |
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| Endotoxin Content: | ≤1 EU/µg |
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| Reconstitution: | Reconstitute in sterile water at 1 mg/mL. Do not vortex. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Handling: | Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. For long term storage, it is recommended to dilute to working aliquots in a 0.1% BSA solution. |
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| Scientific Background: | Human interferon-γ (IFN-γ) is an inflammatory cytokine secreted by T lymphocytes and natural killer (NK) cells. IFN-γ is primarily characterized as an activator of macrophages, and is the principle cytokine produced by CD4+ inflammatory TH1 cells. IFN-γ signals are transmitted via a heterodimeric IFNGR1/IFNGR2 receptor which activates transcription of immunoregulatory genes via the Jak/Stat pathway. |
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| Regulatory Status: | RUO - Research Use Only |
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