| ENZ-ABS374-0100 | 100 µg | 570.00 USD |  |
||
| Do you need bulk/larger quantities? | |||||
| Alternative Name: | TRP53, Tumor protein p53 |
| Clone: | TP53/1799R |
| Host: | Rabbit |
| Isotype: | IgGκ |
| Immunogen: | Recombinant human p53. |
| UniProt ID: | P04637 |
| Species reactivity: | Human |
| Specificity: | Recognizes the mutant as well as the wild form of p53. |
| Applications: | Flow Cytometry, IF, IHC (PS), WB |
| Recommended Dilutions/Conditions: | Flow Cytometry (0.5-1 µg/106 cells in 0.1 mL) Immunofluorescence (0.5-1 µg/mL) Immunohistochemistry (formalin-fixed paraffin sections) (0.25-0.5 µg/mL for 30 minutes at RT) Western blot (0.5-1 µg/mL) Suggested dilutions/conditions may not be available for all applications. Optimal conditions must be determined individually for each application. |
| Purity Detail: | Protein A affinity purified. |
| Formulation: | Liquid. In 1X PBS containing 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. |
| Shipping: | Blue Ice |
| Long Term Storage: | +4°C |
| Scientific Background: | p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma. |
| Regulatory Status: | RUO - Research Use Only |
 |
|
| Download as PDF | |
