Zinquin ethyl ester is a lipophilic, zinc-sensitive, fluorescent derivative of Zinquin that is able to penetrate cell membranes. Cleavage of the ethyl ester group via cytosolic esterases in living cells impedes its efflux across the plasma membrane. It is selective for Zn (II) in the presence of physiological concentrations of Ca (II) and Mg (II) ions. Fluorescence of Zinquin ethyl ester is enhanced upon binding Zn (II), but the probe does not demonstrate a shift or change in emission wavelength. The probe is UV-excitable and emits in the blue reqion of the spectrum. Zinquin ethyl ester has been used to monitor intracellular zinc fluxes associated with apoptosis. Wavelength Maxima: Excitation 368nm, Emission 490nm
Product Details
| Alternative Name: | 2-Methyl-8-(4-methylphenylsulfonylamino)quinolinyl)oxyacetic acid ethyl ester |
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| Formula: | C21H22N2O5S |
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| MW: | 414.5 |
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| CAS: | 181530-09-6 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to pale-blue crystalline solid. |
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| Solubility: | Soluble in DMSO; slightly soluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least one year after receipt when stored as recommended. |
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| Handling: | Protect from light. Keep cool and dry. |
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| Technical Info/Product Notes: | This product is a member of the CELLESTIAL® product line, reagents and assay kits comprising fluorescent molecular probes that have been extensively benchmarked for live cell analysis applications. CELLESTIAL® reagents and kits are optimal for use in demanding imaging applications, such as confocal microscopy, flow cytometry and HCS, where consistency and reproducibility are required. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
New Triazacycloalkane Derivatives as Cytotoxic Agents for CLL Treatment: From Proof of Concept to the Targeting Biomolecule: A. Marlin, et al.; Bioconjug. Chem.
33, 1377 (2022),
Abstract;
Intracellular zinc during cell activation and zinc deficiency: B. Rolles, et al.; J. Trace Elem. Med. Biol.
68, 126864 (2021),
Abstract;
Expression of ZnT and ZIP zinc transporters in the human RPE and their regulation by neurotrophic factors: K.W. Leung, et al.; Invest. Ophthalmol. Vis. Sci.
49, 1221 (2008),
Abstract;
The level of free intracellular zinc mediates programmed cell death/cell survival decisions in plant embryos: A. Helmersson, et al.; Plant Physiol.
147, 1158 (2008),
Abstract;
General Literature References
Cellular zinc fluxes and the regulation of apoptosis/gene-directed cell death.: A.Q. Truong-Tran, et al.; J. Nutr.
130, 1459S (2000),
Abstract;
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