Alternative Name: | Hakata antigen, Ficolin-3 |
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Clone: | FCN334 |
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Host: | Mouse |
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Isotype: | IgG1κ |
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Immunogen: | Recombinant human H-ficolin. |
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UniProt ID: | O75636 |
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GenBank ID: | 8547 |
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Species reactivity: | Human
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Crossreactivity: | No cross-reaction has been observed with L- or M-ficolin. |
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Applications: | ELISA
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Formulation: | Liquid. In 0.01M phosphate buffer, pH 7.4, containing 0.14M sodium chloride and 15mM sodium azide. |
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Shipping: | Blue Ice Not Frozen |
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Long Term Storage: | +4°C |
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Scientific Background: | H-Ficolin (Hakata antigen, Ficolin-3) is an innate immunity pattern recognition molecule found in human serum. H-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) formed by carbohydrates (GlcNAc, GalNAc and fucose) activating complement through the lectin pathway by means of the associated MASPs ((MBL)-associated serine proteases). H-Ficolin consists of 35kDa protein chains associated in triplet subunits, which are again associated in high molecular weight oligomers by means of disulfide bonds at the N-terminal region. |
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Regulatory Status: | RUO - Research Use Only |
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