Potent inhibitor of Tankyrase 1 (IC50=11nM) and Tankyrase 2 (IC50=4nM). Inhibition of tankyrase promotes stabilization of axin resulting in β-catenin degradation and Wnt signalling disruption. Inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Promotes cardiomyogenic development in mesoderm progenitor cells.
Product Details
| Alternative Name: | 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one |
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| Formula: | C14H11F3N2OS |
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| MW: | 312.3 |
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| CAS: | 284028-89-3 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (20 mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Solutions can be stored at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling: S. Huang, et al.; Nature
461, 614 (2009),
Abstract;
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