Replaces Prod. #: ALX-350-020
Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Inhibits fMLP induced PIP3 and superoxide anion production (IC50 = 50nM) in guinea pig neutrophils and blocks the metabolic effects of insulin in isolated rat adipocytes without affecting the insulin receptor tyrosine kinase activity. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase. The half-life of wortmannin in culture media is quite short (8-13 minutes), care should be taken to account for this decomposition when planning experiments. Markedly potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau.
Product Details
| Alternative Name: | KY 12420 |
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| Formula: | C23H24O8 |
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| MW: | 428.4 |
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| Source: | Isolated from Penicillium wortmannii |
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| CAS: | 19545-26-7 |
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| MI: | 14: 10053 |
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| RTECS: | CB9641000 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (50mg/ml), methanol (5mg/ml) or 100% ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Make solutions fresh immediately before use. DO NOT STORE SOLUTIONS. |
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| Technical Info/Product Notes: | Replacement for ADI-HPK-114. |
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| Regulatory Status: | RUO - Research Use Only |
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