3-O-Methyl-Sphingomyelin is a novel selective inhibitor of neutral sphingomyelinase, (Ki=37 µM). It is cell-permeable and does not inhibit acid sphingomyelinase.
Product Details
| Formula: | C32H65N2O6P |
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| MW: | 604.8 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in ethanol (>25 mg/ml) or DMSO (20 mg/ml@50°C). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antisense oligonucleotide activity in tumour cells is influenced by intracellular LBPA distribution and extracellular vesicle recycling: A.N. Kapustin, et al.; Commun. Biol.
4, 1241 (2021),
Abstract;
Ketamine, a Clinically Used Anesthetic, Inhibits Vascular Smooth Muscle Cell Proliferation via PP2A-Activated PI3K/Akt/ERK Inhibition: Y. Chang, et al.; Int. J. Mol. Sci.
18, 2545 (2017),
Abstract;
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