Product Details
| MW: | ~30 kDa |
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| Source: | Produced in E. coli. Human 14-3-3s is fused at the C-terminus to a His-tag. |
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| UniProt ID: | P31947 |
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| Formulation: | Liquid. In 50mM NaH2PO4, pH 8.0, 300mM NaCl. |
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| Purity: | ≥90% (SDS-PAGE) |
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| Purity Detail: | Purified by multi-step chromatography. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | 14-3-3 proteins are dimeric phosphoserine/phosphothreonine binding proteins, which have been shown to be involved in the regulation of many crucial processes such as signal transduction, cell-cycle control, apoptosis, protein localization, phosphorylation state and stability, transcription, metabolism, and malignant transformation. 14-3-3σ is the main 14-3-3 isoform that has been directly implicated in the development of cancer. The 14-3-3σ gene is directly regulated by p53 and is silenced by CpG methylation in a large number of carcinomas. |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
C-TAK1 interacts with microphthalmia-associated transcription factor, Mitf, but not the related family member Tfe3: T. Schwarz, et al.; BBRC
394, 890 (2010),
Abstract;
