Replaces Prod. #: ALX-200-310
Product Details
| Source: | Isolated from human neutrophils. Active enzyme. Negative for HbsAg, anti-HBc, anti-HCV, and anti-HIV-1 and -2. |
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| CAS: | 56645-49-9 |
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| UniProt ID: | P08311 |
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| Formulation: | Lyophilized. |
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| Purity: | ≥95% by SDS-PAGE |
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| Specific Activity: | 2 to 4 units per mg protein. One unit of activity is defined as the amount of enzyme that hydrolyzes one micromole of Suc-Ala-Ala-Pro-Phe-pNA (1mM) per minute at 25°C in 160mM TRIS-HCl, pH 7.4, containing 1.6M sodium chloride. |
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| Application Notes: | Useful for inhibitor screening, kinetic studies, and cleavage of substrates in vitro or in tissue culture. |
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| Reconstitution: | Reconstitute with 50 mM sodium acetate, pH5.5, containing 150 mM NaCl. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | Cathepsin G, a serine protease found in polymorphonuclear neutrophils (PMNs), functions in inflammation. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The Stressed Gut: Region-specific Immune and Neuroplasticity Changes in Response to Chronic Psychosocial Stress: B. Lobo, et al.; J. Neurogastroenterol. Motil.
29, 72 (2023),
Abstract;
Protective role of casuarinin from Melastoma malabathricum against a mouse model of 5-fluorouracil–induced intestinal mucositis: Impact on inflammation and gut microbiota dysbiosis: K.J. Chen, et al.; Phytomedicine
101, 154092 (2022),
Abstract;
Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor Xia: S. Kar, et al.; Pharmaceuticals
14, 886 (2021),
Abstract;
Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis: J. Guo, et al.; Drug Des. Devel. Ther.
13, 581 (2019),
Application(s): stimulate HaCaT response w/ different dosing of Cathepsin G,
Abstract;
Full Text
Cell penetrable, clickable and tagless activity-based probe of human cathepsin L: D. Dana, et al.; Bioorg. Chem.
85, 505 (2019),
Application(s): Activity assay,
Abstract;
Discovery and validation of 2-styryl substituted benzoxazin-4-ones as a novel scaffold for rhomboid protease inhibitors: P. Goel, et al.; Bioorg. Med. Chem. Lett.
28, 1417 (2018),
Abstract;
The putative role of Rhipicephalus microplus salivary serpins in the tick-host relationship: L. Tirloni, et al.; Insect Biochem. Mol. Biol.
71, 12 (2016),
Application(s): Protease inhibition assay,
Abstract;
Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.)
50, 10875 (2014),
Abstract;
Development of cell-active non-peptidyl inhibitors of cysteine cathepsins: D. Dana, et al.; Bioorg. Med. Chem.
21, 2975 (2013),
Abstract;
