Product Details
| Alternative Name: | TCPTP, T cell PTP |
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| MW: | 38 kDa |
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| Source: | Produced in E. coli. T-cell phosphatase with a C-terminal 11 kDa deletion (TCΔC11) (aa 1-317). |
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| UniProt ID: | P17706 |
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| Formulation: | Liquid. In 50mM Tris-HCl, pH 7.0 containing 100 mM NaCl, 2 mM EDTA, 5 mM DTT, 0.01% Brij35 and 30% glycerol. |
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| Purity: | ≥95% (SDS-PAGE) |
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| Purity Detail: | Contains no detectable protease, DNase, RNase, or Ser/Thr phosphatase activity. |
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| Specific Activity: | One unit will release 1 nmol p-nitrophenol per minute at 30°C from 50mM p-nitrophenyl phosphate in 25mM TRIS/HCl, 50mM NaCl, 2mM EDTA, 5mM DTT, 0.01% Brij35, 1mg/ml BSA, pH 7.0. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Regulatory Status: | RUO - Research Use Only |
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SDS-PAGE Analysis: Lane 1: MWM; Lane 2: 0.5 µg of purified T-cell protein tyrosine phosphatase.
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Product Literature References
Identification and evaluation of magnolol and chrysophanol as the principle protein tyrosine phosphatase-1B inhibitory compounds in a Kampo medicine, Masiningan: T. Onoda, et al.; J. Ethnopharmacol.
186, 84 (2016),
Application(s): PTP assay,
Abstract;
The myeloperoxidase-derived oxidant hypothiocyanous acid inhibits protein tyrosine phosphatases via oxidation of key cysteine residues: N.L. Cook, et al.; Free Radic. Biol. Med.
90, 195 (2016),
Abstract;
The two interfaces of the STAT1 N-terminus exhibit opposite functions in IFNγ-regulated gene expression: J. Staab, et al. ; Mol. Immunol.
67, 596 (2015),
Application(s): In vitro dephosphorylation assay,
Abstract;
