| Alternative Name: | Proteasome maturation protein, UMP1 homolog |
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| Host: | Rabbit |
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| Immunogen: | Synthetic peptide corresponding to aa 129-141 of human POMP. |
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| UniProt ID: | Q9Y244 |
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| Species reactivity: | Human, Rat
Monkey
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| Applications: | IHC, IP, WB
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| Purity Detail: | Purified by salt precipitation and peptide immunochromatography. |
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| Formulation: | Liquid. In PBS containing 0.01% sodium azide. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Scientific Background: | The assembly of individual mammalian proteasome subunits into catalytically active 20S proteasome is a complex process, with biogenesis of the mammalian 20S proteasome occuring via precursor complexes containing α and unprocessed β subunits. The pro-peptides of the β subunits are thought to prevent premature conversion of the precursor complexes into matured particles and are needed for efficient β subunit incorporation. The complex biogenesis is tightly regulated, requiring additional components such as the maturation factor POMP (proteasome maturation protein), an ubiquitous protein in eukaryotic cells. Mammalian POMP is functionally related to but not interchangable with its yeast homologue Ump1. POMP is associated purely with the precursor intermediates and is degraded upon final maturation. Northern blot experiments have revealed that expression of POMP is induced after treatment with interferon γ. |
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| Regulatory Status: | RUO - Research Use Only |
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