Replaces Prod. #: ALX-270-166
The tyrphostins are well known tyrosine kinase inhibitors. However, tyrphostin 8 has been shown to inhibit calcineurin (IC50=21 µM) while displaying weak inhibition of EGFR tyrosine kinase (IC50=560 µM).
Product Details
| Alternative Name: | α-Cyano-(4-hydroxy)cinnamonitrile |
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| Formula: | C10H6N2O |
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| MW: | 170.2 |
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| CAS: | 3785-90-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Light orange solid. |
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| Solubility: | Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Handling: | Store tightly sealed in the dark. Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition of calcineurin by the tyrphostin class of tyrosine kinase inhibitors: B.L. Martin; Biochem. Pharmacol.
56, 483 (1998),
Abstract;
Inhibition of GTP-utilizing enzymes by tyrphostins: G. Wolbring, et al.; J. Biol. Chem.
269, 22470 (1994),
Abstract;
Tyrosine phosphorylation is an obligatory event in IL-2 secretion: J.B. Stanley, et al.; J. Immunol.
145, 2189 (1990),
Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem.
32, 2344 (1989),
Abstract;
