Replaces Prod. #: ALX-430-044
Synthetic type II pyrethroid. Potent calcineurin (protein phosphatase 2B) inhibitor IC50~0.03 nM. May also have varied effects on ion channels. Serious doubts have been raised about the efficacy of this inhibitor.
Product Details
| Alternative Name: | Alphamethrine, Pestanal, (R,S)-α-Cyano-3-phenoxybenzyl(1RS)-cis,trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylate |
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| Formula: | C22H19Cl2NO3 |
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| MW: | 416.3 |
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| CAS: | 52315-07-8 |
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| MI: | 14: 2767 |
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| RTECS: | GZ1250000 |
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| Purity: | ≥96% (HPLC) (mixture of isomers:racemic and cis/trans) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in ethanol (25mg/ml). Insoluble in water. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Class II pyrethroids: noninhibitors calcineurin: A. Enz & E. Pombo-Villar; Biochem. Pharmacol.
54, 321 (1997),
Abstract;
Inhibition of phosphatase 2B prevents expression of hippocampal long-term potentiation: J.H. Wang & A. Stelzer; Neuroreport
5, 2377 (1994),
Abstract;
Nerve membrane Na+ channels as targets of insecticides: T. Narahashi; Trends Pharmacol. Sci.
13, 236 (1992),
Abstract;
Specific inhibition of calcineurin by type II synthetic pyrethroid insecticides: E. Enan & F. Matsumura; Biochem. Pharmacol.
43, 1777 (1992),
Abstract;
