A potent and selective inhibitor of prolyl endopeptidase (PEP/PREP/POP, EC 3.4.21.26). Ki=0.35 nM for mouse brain enzyme. Inhibits the cleavage of arginine-vasopressin, gonadotropin-releasing hormone, and other peptides.
Product Details
| Alternative Name: | Z-PP-CHO |
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| Sequence: | Z-Pro-Pro-CHO |
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| Formula: | C18H22N2O4 |
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| MW: | 330.4 |
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| CAS: | 86925-97-5 |
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| Purity: | ≥97% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Exploring Renal Changes after Bariatric Surgery in Patients with Severe Obesity: A. Oliveras, et al.; J. Clin. Med.
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A pressor dose of angiotensin II has no influence on the angiotensin‐converting enzyme 2 and other molecules associated with SARS‐CoV‐2 infection in mice: Y. Wang, et al.; FASEB J.
35, 21419 (2021),
Abstract;
Both Specific Endothelial and Proximal Tubular Adam17 Deletion Protect against Diabetic Nephropathy: V. Palau, et al.; Int. J. Mol. Sci.
22, 5520 (2021),
Abstract;
SARS-CoV-2 Infection Modulates ACE2 Function and Subsequent Inflammatory Responses in Swabs and Plasma of COVID-19 Patients: L. Gutiérrez-Chamorro, et al.; Viruses
13, 1715 (2021),
Abstract;
