Replaces Prod. #: ALX-340-045
Biosynthesis from dihomo-γ-linolenic acid. Stimulates renin release. Antitumor activity. Inhibits NFκB activation in several human cell lines. Induces the synthesis of heat shock proteins. Activates PPARs in human osteosarcoma cells at 10μM.
Product Details
| Alternative Name: | PGA1 |
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| Formula: | C20H32O4 |
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| MW: | 336.5 |
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| CAS: | 14152-28-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in 100% ethanol (50mg/ml), DMSO (50mg/ml) or PBS pH7.2 (2.4mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase: A. Rossi et al.; Nature
403, 103 (2000),
Abstract;
Inhibition of nuclear factor kappa B by prostaglandin A1: an effect associated with heat shock transcription factor activation: A. Rossi et al.; Proc. Natl. Acad. Sci. USA
94, 746 (1997),
Abstract;
Modulation of prostaglandin A1-induced thermotolerance by quercetin in human leukemic cells: role of heat shock protein 70: G. Elia et al.; Cancer Res.
56, 210 (1996),
Abstract;
Differential activation of peroxisome proliferator-activated receptors by eicosanoids: K. Yu et al.; J. Biol. Chem.
270, 23975 (1995),
Abstract;
Induction of thermotolerance by prostaglandin A in human cells: C. Amici et al.; Exp. Cell Res.
207, 230 (1993),
Abstract;
Growth inhibition of Friend erythroleukaemia cell tumours in vivo by a synthetic analogue of prostaglandin A: an action independent of natural killer-activity: S. Marini et al.; Br. J. Cancer
61, 394 (1990),
Abstract;
Induction of renin release by exogenous prostaglandins in hyporeninemic hypoaldosteronism: J. Hahn et al.; Prostaglandins
20, 15 (1980),
Abstract;
