Potent agonist for contraction of smooth muscle. Induces microvascular permeability and mucus secretion in airways. Enhances growth of human airway epithelial cells. Reduces myocardial contractility and coronary blood flow. Induces long lasting hypotension. Biosynthesis from LTC4 by γ-glutamyltranspeptidase.
Product Details
| Alternative Name: | LTD4 |
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| Formula: | C25H40N2O6S |
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| MW: | 496.7 |
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| Source: | Synthetic. |
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| CAS: | 73836-78-9 |
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| Concentration: | 50 µg/ml |
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| Formulation: | Solution in methanol/ammonium acetate buffer, 70:30, pH 5.6. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Liquid. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -80°C. Protect from exposure to air. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Abstract;
Leukotrienes and inflammation: S. D. Brain & T. J. Williams; Pharmacol. Ther.
46, 57 (1990),
Abstract;
The signal transduction system of the leukotriene D4 receptor: S. T. Crooke, et al.; Trends Pharmacol. Sci.
10, 103 (1989),
Abstract;
Leukotrienes as mediators of ischemia and shock: A. M. Lefer, et al.; Biochem. Pharmacol.
35, 123 (1986),
Abstract;
Metabolism of leukotrienes: S. Hammarström, et al.; Mol. Cell Biochem.
69, 7 (1985),
Abstract;
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