Unstable intermediate in the biosynthesis of LTB4 and LTC4. The naturally occuring free acid is a substrate for LTA4 hydrolase and LTC4 synthase and plays a central role in transcellular leukotrieneand lipoxin biosynthesis. Mobilizes Ca2+ in human neutrophils. Supplied as the methyl ester for greater stability.
Product Details
| Alternative Name: | LTA4-ME |
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| Formula: | C21H32O3 |
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| MW: | 332.5 |
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| Source: | Synthetic. |
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| CAS: | 73466-12-3 |
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| Concentration: | 1 mg/ml |
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| Formulation: | Oil dissolved in 2% triethylamine/hexane. |
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| Purity: | ≥95% (HPLC) (remainder 11-trans isomer) |
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| Appearance: | Liquid. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -80°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Ca2+ mobilization with leukotriene A4 and epoxytetraenes in human neutrophils: F. Luscinskas, et al.; Biochem. Pharmacol.
39, 355 (1990),
Abstract;
Formation of lipoxins and leukotrienes during receptor-mediated interactions of human platelets and recombinant human granulocyte/macrophage colony-stimulating factor-primed neutrophils: S. Fiore & C. N. Serhan; J. Exp. Med.
172, 1451 (1990),
Abstract;
Full Text
Enzymes involved in the biosynthesis of leukotriene B4: B. Samuelsson & C. D. Funk; J. Biol. Chem.
264, 19469 (1989),
Abstract;
Full Text
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects: B. Samuelsson, et al.; Science
237, 1171 (1987),
Abstract;
