A unique and selective ATP-sensitive K+ channel (KATP) opener (EC50=0.5 μM) which is short acting. Completely abolishes overactivity in a rat model of overactive bladder.
Product Details
| Alternative Name: | N-(4-Phenylsulfonylphenyl)-3,3,3-trifluoro-2-hydroxy-2-methylpropanamide |
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| Formula: | C16H14F3NO4S |
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| MW: | 373.4 |
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| CAS: | 147695-92-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or ethanol (>25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibitory effects of different ATP-sensitive potassium channel openers on electrically generated and carbachol-induced contractions of porcine and human detrusor muscle: J.K. Badawi, et al.; Fundam. Clin. Pharmacol.
22, 75 (2008),
Abstract;
Effect of the ATP-sensitive potassium channel opener ZM226600 on cystometric parameters in rats with ligature-intact, partial urethral obstruction: C. Pinna, et al.; Eur. J. Pharmacol.
516, 71 (2005),
Abstract;
