α-Dendrotoxin is isolated from Dendroaspis angusticeps snake venom, by modification of the procedures of Harvey and Benishin and purified to homogeneity. α-Dendrotoxin blocks Kv1.1 and Kv1.2 channels (IC50= 0.4 to 4 and 1.1 to 12 nM in oocytes respectively, with higher values for mammalian cells). In addition, the toxin was shown to block also Kv1.6 (IC50= 9-25 nM).
Product Details
| Sequence: | Gln-Pro-Arg-Arg-Lys-Leu-Cys-Ile-Leu-His-Arg-Asn-Pro-Gly-Arg-Cys-Tyr-Asp-Lys-Ile-Pro-Ala-Phe-Tyr-Tyr-Asn-Gln-Lys-Lys-Lys-Gln-Cys-Glu-Arg-Phe-Asp-Trp-Ser-Gly-Cys-Gly-Gly-Asn-Ser-Asn-Arg-Phe-Lys-Thr-Ile-Glu-Glu-Cys-Arg-Arg-Thr-Cys-Ile-Gly |
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| MW: | 7048.1 |
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| CAS: | 74504-53-3 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Lyophilized solid. |
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| Solubility: | Soluble in any aqueous buffer. Please centrifuge all product preparations at 10000 x g for 5 minutes before reconstitution. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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General Literature References
Dendrotoxin poisoning in a neurobiochemist: S.W. Munday, et al.; J. Toxicol. Clin. Toxicol.
41, 163 (2003),
Abstract;
