Stimulates neutrophil degranulation and Ca2+ mobilization by a mechanism independent of the LTB4 receptor. Has been shown to act as an agonist at a G protein-coupled receptor (R527). Induces the infiltration of granulocytes into human skin.
Product Details
| Formula: | C20H30O3 |
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| MW: | 318.5 |
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| CAS: | 106154-18-1 |
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| Concentration: | 50 µg/ml |
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| Formulation: | Oil dissolved in ethanol |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Liquid. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Store, as supplied, at -80°C for up to 1 year. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
5-oxo-6,8,11,14-eicosatetraenoic acid induces the infiltration of granulocytes into human skin: S. Muro, et al.; J. Allergy Clin. Immunol.
112, 768 (2003),
Abstract;
Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils: C.E. Jones, et al.; Mol. Pharmacol.
63, 471 (2003),
Abstract;
Full Text
5-Oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of human eosinophil migration: W.S. Powell, et al.; J. Immunol.
154, 4123 (1995),
Abstract;
5-Oxo-eicosanoids are potent eosinophil chemotactic factors. Functional characterization and structural requirements: U. Schwenk & J.M. Schroeder ; J. Biol. Chem.
270, 15029 (1995),
Abstract;
Formation of a 5-oxo metabolite of 5,8,11,14,17-eicosapentaenoic acid and its effects on human neutrophils and eosinophils: W.S. Powell, et al.; J. Lipid Res.
36, 2590 (1995),
Abstract;
Full Text
5-Oxo-eicosatetraenoate, a potent human neutrophil stimulus: J.T. O'Flaherty, et al.; Biochem. Biophys. Res. Commun.
192, 129 (1993),
Abstract;
