Tubacin (tubulin acetylation inducer) is a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6 (IC50=0.004µM). IC50's for the other HDACs are 1000-fold higher, making tubacin both more selective and more potent than Tubastatin A, which also inhibits HDAC8. Concentration in cell culture experiments typically ranges from 2-50µM.
Product Details
| Alternative Name: | N-(4-{(2R,4R,6S)-4-{[(4,5-diphenyl-1,3-oxazol-2-yl)sulfanyl]methyl}-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl}phenyl)-N'-hydroxyoctanediamide |
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| Formula: | C41H43N3O7S |
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| MW: | 721.9 |
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| Source: | Synthetic. |
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| CAS: | 537049-40-4 |
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| Purity: | ≥96% (ELSD) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (10 mg/ml). |
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| Shipping: | Dry Ice |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -80°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
A live-cell marker to visualize the dynamics of stable microtubules throughout the cell cycle: K.I. Jansen, et al.; J. Cell Biol.
222, e202106105 (2023),
Abstract;
Histone deacetylase-6 modulates the effects of 4°C platelets on vascular endothelial permeability: B. Miyazawa, et al.; Blood Adv.
7, 1241 (2023),
Abstract;
Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation: Y. Nomura, et al.; Front. Physiol.
12, 675724 (2021),
Abstract;
LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma: M. Nassar, et al.; Sci. Rep.
7, 8022 (2017),
Application(s): Measurement of cell index against different concentration,
Abstract;
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Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin A: K.V. Butler, et al.; J. Am. Chem. Soc.
370, 10842 (2010),
Abstract;
Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents: M. Namdar, et al.; Proc. Natl. Acad. Sci. USA
107, 20003 (2010),
Abstract;
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Tubacin kills Epstein-Barr virus (EBV)-Burkitt lymphoma cells by inducing reactive oxygen species and EBV lymphoblastoid cells by inducing apoptosis: J. Kawada, et al.; J. Biol. Chem.
284, 17102 (2009),
Abstract;
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Histone deacetylase 6 interacts with the microtubule-associated protein tau: H. Ding, et al.; J. Neurochem.
106, 2119 (2008),
Abstract;
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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation: S.J. Haggarty, et al.; Proc. Natl. Acad. Sci. USA
100, 4389 (2003),
Abstract;
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Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays: S.J. Haggarty, et al.; Chem. Biol.
10, 383 (2003),
Abstract;
Structural biasing elements for in-cell histone deacetylase paralog selectivity: J.C. Wong, et al.; J. Am. Chem. Soc.
125, 5586 (2003),
Abstract;
Synthesis of 7200 small molecules based on a substructural analysis of the histone deacetylase inhibitors trichostatin and trapoxin: S.M. Sternson, et al.; Org. Lett.
3, 4239 (2001),
Abstract;
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